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Silyl formates as hydrosilane surrogates for the transfer hydrosilylation of ketones

20 April 2022, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A transfer hydrosilylation of ketones employing silyl formates as hydrosilanes surrogates under mild conditions is presented. A total of 24 examples of ketones have been successfully converted to their corresponding silyl ethers with 61-99% yield in the presence of a PNHP-based ruthenium catalyst and silyl formate reagent. The crucial role of the ligand for the transformation is demonstrated.

Keywords

Silyl formate
surrogate
hydrosilylation
carbonyl reduction
participative ligand

Supplementary materials

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Description
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Supporting information
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Experimental procedures and compilation of spectral and analytical data of all new compounds
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Version History

Apr 20, 2022 Version 2

Version Notes

Additional experiments were added, performed by a new author: Neethu Thyagarajan.

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-ww7pj-v2
D O I: 10.26434/chemrxiv-2022-ww7pj-v2 [opens in a new tab]

Funding

CEA
CNRS
ERC
Consolidator Grant 818260
Labex Charmmmat
ANR-11-LABX-003
Institut de France

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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