Arylboronic Acids Catalyzed Upgrade of Glucosamines for Deoxyfructosazine and Insights on Reaction Mechanism

21 January 2022, Version 4
This content is a preprint and has not undergone peer review at the time of posting.


Chitin is the most abundant N-containing polysaccharides in nature and D-glucosamine is one of most successful commercial monomer products in current market. Here we reported an arylboronic acids catalyzed upgrade of glucosamines in aqueous solution for deoxyfructosazine which is an important high-value compound in pharmaceutical and food industries, as well as a promising bio-based platform molecule for speciality chemicals and sustainable functional materials. Such direct integration of deoxyfructosazine into development of renewable chemicals/functional materials might be a practical way for utilization of chitin as a renewable nitrogen source. A mechanism focusing on catalytic cycle of arylboronic acid via a boron transfer was also proposed.


arylboronic acid catalysis
aqueous solution

Supplementary materials

Supporting information
General procedures for STables, STable contents; HNMR spectra for all tables and STables.


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