Biological and Medicinal Chemistry

Protective effect of starch-stabilized selenium nanoparticles against the hepato-renal melamine-induced toxicity in male albino rats

Authors

  • Zainab Sabry Othman Ahmed Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt ,
  • Mona K. Galal Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt ,
  • Elsayed A. Drweesh Inorganic Chemistry Department, National Research Centre, 33 El Bohouth St. (former Eltahrir St.), Dokki, Giza 12622, Egypt ,
  • Khaled S. Abou-El-Sherbini Inorganic Chemistry Department, National Research Centre, 33 El Bohouth St. (former Eltahrir St.), Dokki, Giza 12622, Egypt ,
  • Eman A.M. Elzahany Inorganic Chemistry Department, National Research Centre, 33 El Bohouth St. (former Eltahrir St.), Dokki, Giza 12622, Egypt ,
  • Mohamed Elnagar Institute of Electrochemistry, Ulm University, Albert-Einstein-Allee 47, 89081 Ulm, Germany ,
  • Noha A. E. Yasin Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt

Abstract

Melamine and its analogues are illegally added to falsify the content of protein in food products. The elevated concentrations of these compounds cause harmful effects in humans and animals. In this contribution, the potential ability of synthesized starch-stabilized selenium nanoparticles ([email protected]) towards inhibiting the toxicity of melamine on the liver and kidneys has been systematically investigated. The [email protected] were characterized by XPS analysis, EDS mapping analysis, TEM, and FT-IR. Starch plays a crucial role in the stabilization and dispersion of Se NPs, as noticed from the TEM and EDS investigations. Furthermore, the atomic ratio of Se distribution over starch surface is approximately 1.67%. To evaluate the activity of [email protected], this study was conducted on four groups of adult male rats. Group I (the control group), group II received [email protected], group III received melamine, whereas group IV received melamine and [email protected] The results reveal a significant alteration in the histoarchitecture of both hepatic and renal tissues induced by melamine. While melamine induces severe toxic effects on the hepatic and renal tissues, the administration of [email protected] results in remarkable protection of rats against melamine-induced toxicity. Collectively, the affordable starch-stabilized Se-NPs have a potent biological activity, making them auspicious candidates for biomedical applications.

Content

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