Concise Chemoenzymatic Synthesis of Fasamycin A

05 March 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report the development of a chemoenzymatic approach towards fasamycin A, a halogenated naphthacenoid that exhibits activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. The synthesis was accomplished in a convergent manner: two fragments were combined together via Michael−Dieckmann condensation to afford a dimethylnaphthacenone system. Finally, an enzymatic halogenation was employed to introduce the requisite chlorine substituent of the natural product at a late stage.

Keywords

antibiotics
natural product
total synthesis
halogenase

Supplementary materials

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Title
Fasamycin A SI Final
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