Green Synthesis: A Novel Method for Bromination of 7-AminoPhthalide

11 January 2021, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A novel method for preparing a bromo substituted 7-Amino-phthalides and 7-
Amino-3-hydroxy-phthalides via the bromonium ion intermediate under acidic conditions at
higher temperature were developed. The results will illustrate the potential utility of this
method as an environment-friendly process for synthesis of bromo substituted aryl amines,
along with conservation of half mole equivalent of halides.

Keywords

7-Amino-phthalide
bromonium ion,
desulfonation,
green chemistry,

Supplementary materials

Title
Description
Actions
Title
Bromination experimental 1-9-2021 ready to submit
Description
Actions
Title
Bromination spectral data-ready to submit on 1-9-2021
Description
Actions

Supplementary weblinks

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.