Green Synthesis: A Novel Method for Bromination of 7-AminoPhthalide

21 September 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A novel method for preparing a bromo substituted 7-Amino-phthalides and 7-
Amino-3-hydroxy-phthalides via the bromonium ion intermediate under acidic conditions at
higher temperature were developed. The results will illustrate the potential utility of this
method as an environment-friendly process for synthesis of bromo substituted aryl amines,
along with conservation of half mole equivalent of halides.

Keywords

7-Amino-phthalide
bromonium ion,
desulfonation,
green chemistry,

Supplementary materials

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Title
Bromination experimental 9-20-2020 Chemrxiv submitted
Description
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Bromination spectral data-9-20-2020 Chemrxiv submitted
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Supplementary weblinks

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