Mechanosynthesis of a Coamorphous Formulation of Creatine with Citric Acid and Humidity–Mediated Transformation into a Cocrystal

29 September 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We report a simple, efficient, and scalable mechanochemical method of preparation of new creatine fitness supplement with increased solubility (compared to the creatine monohydrate) and decreased acidity (compared to creatine hydrochloride).


Crystal Engineering


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