Mechanosynthesis of a Coamorphous Formulation of Creatine with Citric Acid and Humidity–Mediated Transformation into a   Cocrystal

Kyle B Pekar; Jonathan B Lefton; Christina McConville; Jewel Burleson; Daniel Sethio; Elfi Kraka; Tomce Runcevski

doi:10.26434/chemrxiv.13012907.v1

Agriculture and Food Chemistry

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Mechanosynthesis of a Coamorphous Formulation of Creatine with Citric Acid and Humidity–Mediated Transformation into a Cocrystal

29 September 2020, Version 1

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Abstract

We report a simple, efficient, and scalable mechanochemical method of preparation of new creatine fitness supplement with increased solubility (compared to the creatine monohydrate) and decreased acidity (compared to creatine hydrochloride).

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Mechanosynthesis of a Coamorphous Formulation of Creatine with Citric Acid and Humidity-Mediated Transformation into a Cocrystal

Kyle B. Pekar, Jonathan B. Lefton, Christina A. McConville, Jewel Burleson, Daniel Sethio, Elfi Kraka, Tomče Runčevski journal article

Crystal Growth & Design , Volume 21, Issue 2

Online publication date: Jan 04, 2021

Version History

Sep 29, 2020 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.13012907.v1

Author’s competing interest statement

Provisional patent application has been submitted