A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

09 September 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A new route to MK-4482 (1) was developed. The route replaces uridine with the more available and less expensive cytidine. Low cost, simple reagents are used for the chemical transformations and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.

Keywords

antiviral
COVID-19
EIDD-2801
MK-4482
cytidine

Supplementary materials

Title
Description
Actions
Title
2020 09 08 EIDD Cytidine Acetonide SI
Description
Actions

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