Spatially Controlled Glycocalyx Engineering for Growth Factor Patterning in Embryoid Bodies

Matthew
R. Naticchia; Logan K. Laubach; honigfort Daniel J.; purcell Sean C.; Kamil Godula

doi:10.26434/chemrxiv.12755849.v2

Biological and Medicinal Chemistry

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Spatially Controlled Glycocalyx Engineering for Growth Factor Patterning in Embryoid Bodies

19 August 2020, Version 2

Working Paper

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Cell surface engineering with synthetic glycomimetic co-receptors for FGF2 was used to establish gradients of stem cells with enhanced FGF2 affinity in embryoid bodies (EBs). Gradient shape was controlled by pre-assembly of glycomimetics into nanoscale vesicles with tunable dimensions and EB penetrance.

Keywords

Glycocalyx Engineering

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