Biological and Medicinal Chemistry

Spatially Controlled Glycocalyx Engineering for Growth Factor Patterning in Embryoid Bodies

Abstract

Cell surface engineering with synthetic glycomimetic co-receptors for FGF2 was used to establish gradients of stem cells with enhanced FGF2 affinity in embryoid bodies (EBs). Gradient shape was controlled by pre-assembly of glycomimetics into nanoscale vesicles with tunable dimensions and EB penetrance.

Content

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Supplementary material

Thumbnail image of EB remodeling SI_chemarxiv.pdf
EB remodeling SI chemarxiv