Patterning of Growth Factor Gradients in Embryoid Bodies via Extracellular Matrix-Assisted Glycocalyx Engineering

Matthew
R. Naticchia; Logan K. Laubach; honigfort Daniel J.; purcell Sean C.; Kamil Godula

doi:10.26434/chemrxiv.12755849.v1

Biological and Medicinal Chemistry

Search within Biological and Medicinal Chemistry

Patterning of Growth Factor Gradients in Embryoid Bodies via Extracellular Matrix-Assisted Glycocalyx Engineering

This is not the most recent version. There is a

newer version

of this content available

Working Paper

Abstract

Cell surface engineering with synthetic glycomimetic co-receptors for FGF2 was used to establish gradients of stem cells with enhanced FGF2 affinity in embryoid bodies (EBs). Gradient shape was controlled by pre-assembly of glycomimetics into nanoscale vesicles with tunable dimensions and EB penetrance.