Biological and Medicinal Chemistry

Patterning of Growth Factor Gradients in Embryoid Bodies via Extracellular Matrix-Assisted Glycocalyx Engineering

Abstract

Cell surface engineering with synthetic glycomimetic co-receptors for FGF2 was used to establish gradients of stem cells with enhanced FGF2 affinity in embryoid bodies (EBs). Gradient shape was controlled by pre-assembly of glycomimetics into nanoscale vesicles with tunable dimensions and EB penetrance.

Content

Thumbnail image of Matrix mediated EB remodeling_chemarxiv.pdf

Supplementary material

Thumbnail image of EB matrix remodeling SI_chemarxiv.pdf
EB matrix remodeling SI chemarxiv