Organic Chemistry

Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes

Authors

Abstract

We demonstrate the utility of biocatalytic hydroxylation with PtmO6 in the chemoenzymatic total synthesis of three oxidized kaurane natural products.

Content

Thumbnail image of PtmO6 Chemrxiv FINAL.pdf

Supplementary material

Thumbnail image of PtmO6 SI 013119.pdf
PtmO6 SI 013119