Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes

Abstract

We demonstrate the utility of biocatalytic hydroxylation with PtmO6 in the chemoenzymatic total synthesis of three oxidized kaurane natural products.

Content

Supplementary material

PtmO6 SI 013119