Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes

Xiao Zhang; Liao-Bin Dong; Li-Cheng Yang; Jeffrey D. Rudolf; Ben Shen; Hans Renata

doi:10.26434/chemrxiv.7663112.v1

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Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes

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Xiao Zhang ,
Liao-Bin Dong ,
Li-Cheng Yang ,
Jeffrey D. Rudolf ,
Ben Shen ,
Hans Renata The Scripps Research Institute

Abstract

We demonstrate the utility of biocatalytic hydroxylation with PtmO6 in the chemoenzymatic total synthesis of three oxidized kaurane natural products.

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Thumbnail image of PtmO6 Chemrxiv FINAL.pdf

Supplementary material

PtmO6 SI 013119

Version History

Mar 23, 2020 Version 2

Feb 04, 2019 Version 1

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The content is available under CC BY NC ND 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv.7663112.v1

Funding

GM128895

GM114353

Author’s competing interest statement

The authors declare no conflict of interest

Keywords

biocatalysis

total synthesis

C–H functionalization

terpenes

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Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes

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Abstract

Content

Supplementary material

Version History

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License

DOI

Funding

Author’s competing interest statement

Keywords

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