Organic Chemistry

Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes



We demonstrate the utility of biocatalytic hydroxylation with PtmO6 in the chemoenzymatic total synthesis of three oxidized kaurane natural products.


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Supplementary material

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PtmO6 SI 013119