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Abstract
We demonstrate the utility of biocatalytic hydroxylation with PtmO6 in the chemoenzymatic total synthesis of three oxidized kaurane natural products.
Content
Supplementary material
PtmO6 SI 013119
Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes
Working Paper
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Feb 04, 2019 Version
1
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The content is available under CC BY NC ND 4.0 License
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DOI
Funding
GM128895
GM114353
Author’s competing interest statement
The authors declare no conflict of interest
Keywords
biocatalysis
total synthesis
C–H functionalization
terpenes
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This content is an early or alternative research output and has not been
peer-reviewed at the time of posting.