Non-natural sequence-defined polymers have the potential to recapitulate the unique structures and functions of proteins. To achieve this goal requires not only high-efficiency synthesis platforms, but also an understanding of the relationship between sequence and folding/self-assembly. In a step towards that goal, we have here exploited the high-yielding solid phase phosphoramidite synthesis commonly used to make DNA, and generated two sequence-isomeric polymers which display sequence-programmed folding and self-assembly. These findings open up possibilities for more sophisticated sequence/structure relationships using the same synthetic platform.
Sequence Isomerism in Uniform Polyphosphoesters Programmes Self-Assembly and Folding
14 February 2020, Version 2
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.
Sequence isomers ESI v2