Sequence Isomerism in Uniform Polyphosphoesters Programmes Self-Assembly and Folding

04 February 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Non-natural sequence-defined polymers have the potential to recapitulate the unique structures and functions of proteins. To achieve this goal requires not only high-efficiency synthesis platforms, but also an understanding of the relationship between sequence and folding/self-assembly. In a step towards that goal, we have here exploited the high-yielding solid phase phosphoramidite synthesis commonly used to make DNA, and generated two sequence-isomeric polymers which display sequence-programmed folding and self-assembly. These findings open up possibilities for more sophisticated sequence/structure relationships using the same synthetic platform.


Sequence-defined polymers
Single-Chain Nanoparticles

Supplementary materials

C12-HEG ESI v3


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