The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain

David Cheung

doi:10.26434/chemrxiv.7556840.v3

Biological and Medicinal Chemistry

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The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain

10 July 2019, Version 3

Working Paper

David Cheung

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Using enhanced molecular dynamics simulations the structure of the insulin B-chain was investigated at the air-water interface and in bulk solution. Significant differences in the conformational behaviour between these environments were found, with the air-water interface stabilising the formation of alpha-helical structures.

Keywords

protein

air-water interface

molecular dynamics

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