The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain

09 January 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Using enhanced molecular dynamics simulations the structure of the insulin B-chain was investigated at the air-water interface and in bulk solution. Significant differences in the conformational behaviour between these environments were found, with the air-water interface stabilising the formation of alpha-helical structures.


air-water interface
molecular dynamics


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