Working Paper
Authors
- Rohit Bhadoria ,
- Kefeng Ping ,
- Christer Lohk ,
- Ivar Järving ,
- Pavel Starkov
Tallinn University of Technology
Abstract
Conjugation techniques are central to improving intracellular delivery of bioactive small molecules. However, tracking and assessing the overall biological outcome of these constructs remains poorly understood. We addressed this issue by having developed a focused library of heterobivalent constructs based on Rho kinase inhibitors to probe various scenarios. By comparing induction of a phenotype of interest vs. cell viability vs. cellular uptake, we demonstrate that such conjugates indeed lead to divergent cellular outcomes.
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Content

Supplementary material

Bhadoria et al SI