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Biological and Medicinal Chemistry

Working Paper

Probing Cellular Outcomes Using Heterobivalent Constructs

Rohit Bhadoria, Kefeng Ping, Christer Lohk, Ivar Järving, Pavel Starkov

Version 1 posted 22 January 2019

580

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Organic Chemistry

Working Paper

Identification of a privileged scaffold for inhibition of sterol transport proteins through the synthesis and ring distortion of diverse, pseudo-natural products

Frederik Simonsen Bro, Laura Depta, Nienke Dekker, Hogan Bryce-Rogers, Kaia Præstegaard, Tino Petersson, Thomas Whitmarsh-Everiss, Mariusz Kubus, Luca Laraia

Version 1 posted 24 July 2024

270

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Biological and Medicinal Chemistry

Working Paper

Integration of Computational and Experimental Techniques for the Discovery of SARS-CoV-2 PLpro Covalent Inhibitors

Ho Ying Huang, Sharon Pinus, Xiao Cong Zhang, Guanyu Wang, Andrés M Rueda, Yaouba Souaibou, Solène Huck, Mitchell Huot, Danielle Vlaho, Joshua Pottel, Felipe Venegas, Zhuoqun Lu, Christopher Hennecker, Julia Stille, Jevgenijs Tjutrins, Caitlin Miron, Anne Labarre, Jessica Plescia, Mihai Burai-Patrascu, Anthony Mittermaier, Nicolas Moitessier

Version 1 posted 15 September 2023

321

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Biological and Medicinal Chemistry

Working Paper

Structure-Based Optimization and Biological Evaluation of SARS-CoV-2 3CLpro Covalent Inhibitors

Guanyu Wang, Julia Stille, Richard Boulon, Christopher Hennecker, Xiaocong Zhang, Nicole Blaine, Steven Laplante, Anthony Mittermaier, Nicolas Moitessier

Version 1 posted 18 September 2024

113

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Biological and Medicinal Chemistry

Working Paper

Attacking COVID-19 Progression using Multi-Drug Therapy for Synergetic Target Engagement

Mathew Coban, Juliet Morrison, William Freeman, Evette S. Radisky, Karine Le Roch, Thomas Caulfield

Version 2 posted 16 July 2020

997

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Biological and Medicinal Chemistry

Working Paper

Computational Determination of Potential Inhibitors of SARS-CoV-2 Main Protease

Son Tung Ngo, Ngoc Quynh Anh Pham, Ly Le, Duc-Hung Pham, Van Vu

Version 2 posted 02 June 2020

1,523

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Biological and Medicinal Chemistry

Working Paper

Mechanistic Investigations of Metallo-β-Lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition

Nicola Wade, Kamaleddin Tehrani, Nora Brüchle, Matthijs J. van Haren, Vida Mashayekhi, Nathaniel Martin

Version 1 posted 16 November 2020

440

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Biological and Medicinal Chemistry

Working Paper

Exploring aspartic protease inhibitor binding to design selective antimalarials

Raitis Bobrovs, Emils Basens, Laura Drunka, Iveta Kanepe, Sofija Matisone, Karlis Velins, Victor Andrianov, Gundars Leitis, Diana Zelencova-Gopejenko, Dace Rasina, Aigars Jirgensons, Kristaps Jaudzems

Version 1 posted 31 January 2022

422

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Biological and Medicinal Chemistry

Working Paper

Investigating Novel Thiazolyl-Indazole Derivatives as Scaffolds for SARS-CoV-2 MPro Inhibitors

Justin Airas, Catherine A. Bayas, Abdellah N'Ait Ousidi, My Youssef Ait Itto, Aziz Auhmani, Mohamed Loubidi, M'hamed Esseffar, Julie A. Pollock, Carol A. Parish

Version 2 posted 14 July 2021

574

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Biological and Medicinal Chemistry

Working Paper

Ultrafast and Selective Labeling of Endogenous Proteins Using Affinity-based Benzotriazole Chemistry

Xiaoyi Xin, Yu Zhang, Massimiliano Gaetani, Susanna Lundström, Roman Zubarev, Yuan Zhou, Dale Corkery, Yaowen Wu

Version 2 posted 01 June 2022

631

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30 results in inhibitors in Keywords: inhibitors

Probing Cellular Outcomes Using Heterobivalent Constructs

Identification of a privileged scaffold for inhibition of sterol transport proteins through the synthesis and ring distortion of diverse, pseudo-natural products

Integration of Computational and Experimental Techniques for the Discovery of SARS-CoV-2 PLpro Covalent Inhibitors

Structure-Based Optimization and Biological Evaluation of SARS-CoV-2 3CLpro Covalent Inhibitors

Attacking COVID-19 Progression using Multi-Drug Therapy for Synergetic Target Engagement

Computational Determination of Potential Inhibitors of SARS-CoV-2 Main Protease

Mechanistic Investigations of Metallo-β-Lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition

Exploring aspartic protease inhibitor binding to design selective antimalarials

Investigating Novel Thiazolyl-Indazole Derivatives as Scaffolds for SARS-CoV-2 MPro Inhibitors

Ultrafast and Selective Labeling of Endogenous Proteins Using Affinity-based Benzotriazole Chemistry

30 results in Keywords: inhibitors