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Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

preprint
revised on 18.05.2020, 15:55 and posted on 19.05.2020, 07:23 by Nathan Renier, Olivia Reinaud, Ivan Jabin, Hennie Valkenier
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu+ transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu+ into chloroform. Transmembrane transport of Cu+ into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu+ ionophores for biomedical applications.

Funding

Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-FRS, Belgium)

Fonds de la Recherche Scientifique-FNRS, HV is a Chercheuse Qualifiée

European Research Council (ERC starting grant 802727)

Fonds Van Buuren

Fonds Defay

History

Email Address of Submitting Author

Hennie.Valkenier@ulb.ac.be

Institution

Université libre de Bruxelles

Country

Belgium

ORCID For Submitting Author

0000-0002-2557-6116

Declaration of Conflict of Interest

No conflict of interest to declare

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