ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

preprint
revised on 18.05.2020 and posted on 19.05.2020 by Nathan Renier, Olivia Reinaud, Ivan Jabin, Hennie Valkenier
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu+ transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu+ into chloroform. Transmembrane transport of Cu+ into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu+ ionophores for biomedical applications.

Funding

Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-FRS, Belgium)

Fonds de la Recherche Scientifique-FNRS, HV is a Chercheuse Qualifiée

European Research Council (ERC starting grant 802727)

Fonds Van Buuren

Fonds Defay

History

Email Address of Submitting Author

Hennie.Valkenier@ulb.ac.be

Institution

Université libre de Bruxelles

Country

Belgium

ORCID For Submitting Author

0000-0002-2557-6116

Declaration of Conflict of Interest

No conflict of interest to declare

Exports