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Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

revised on 18.05.2020, 15:55 and posted on 19.05.2020, 07:23 by Nathan Renier, Olivia Reinaud, Ivan Jabin, Hennie Valkenier
Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu+ transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu+ into chloroform. Transmembrane transport of Cu+ into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu+ ionophores for biomedical applications.


Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-FRS, Belgium)

Fonds de la Recherche Scientifique-FNRS, HV is a Chercheuse Qualifiée

European Research Council (ERC starting grant 802727)

Fonds Van Buuren

Fonds Defay


Email Address of Submitting Author


Université libre de Bruxelles



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest to declare