Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

29 April 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu+ transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu+ into chloroform. Transmembrane transport of Cu+ into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu+ ionophores for biomedical applications.

Keywords

supramolecular chemistry
Cell and Molecular Biology
Transport Phenomena
transmembrane transporter

Supplementary materials

Title
Description
Actions
Title
SI CuTransport
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.