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Coban_et-al_FinalCombined-RXIV_submit3260546.pdf (2.71 MB)

Attacking COVID-19 Progression using Multi-Drug Therapy for Synergetic Target Engagement

preprint
revised on 07.07.2020 and posted on 16.07.2020 by Mathew Coban, Juliet Morrison, William Freeman, Evette S. Radisky, Karine Le Roch, Thomas Caulfield
We are presenting our on going studies with inhibitory research on Tmprss2, S-protein:Ace2, and 3CLpro using compound screening coupled with X-ray crystallography, molecular modeling, live virus screening using host human cells (BSL3 facility at UC Center for Infectious Disease and Vector Research, and organ-on-a-chip at Harvard Medical School for safety profiling before proceeding to animal models with InVivo BioSystems for ADMET.
We have derived a useful chemical toolkit of 350 compounds for the community to study with biochemical assays and other biophysical-chemical studies that will prove useful in searching for optimal inhibitors of these targets to find suitable pharmacophores for blocking each of these enzyme's activities -- that would be beneficial for human health. Our past successes with these methodologies have resulted in over 28 patents, 11 technologies and two startup companies.

Funding

No external funding.

History

Email Address of Submitting Author

caulfield.thomas@mayo.edu

Institution

Mayo Clinic

Country

United States

ORCID For Submitting Author

0000-0002-1055-3069

Declaration of Conflict of Interest

Author's declare there are no conflicts of interest.

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