ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

preprint
submitted on 05.04.2018 and posted on 09.04.2018 by Jonathan J. Mills, Kaylib R. Robinson, Troy E. Zehnder, Joshua G. Pierce
The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Funding

NIH (1R01GM110154)

History

Email Address of Submitting Author

jgpierce@ncsu.edu

Institution

NC State University

Country

United States

ORCID For Submitting Author

0000-0001-9194-3765

Declaration of Conflict of Interest

No Conflict of Interest

Exports