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Sequence Isomerism in Uniform Polyphosphoesters Programmes Self-Assembly and Folding

preprint
revised on 13.02.2020 and posted on 14.02.2020 by Nadeema Appukutti, Joseph Jones, Christopher Serpell

Non-natural sequence-defined polymers have the potential to recapitulate the unique structures and functions of proteins. To achieve this goal requires not only high-efficiency synthesis platforms, but also an understanding of the relationship between sequence and folding/self-assembly. In a step towards that goal, we have here exploited the high-yielding solid phase phosphoramidite synthesis commonly used to make DNA, and generated two sequence-isomeric polymers which display sequence-programmed folding and self-assembly. These findings open up possibilities for more sophisticated sequence/structure relationships using the same synthetic platform.

Funding

University of Kent

Royal Society of Chemistry Research Fund

History

Email Address of Submitting Author

c.j.serpell@kent.ac.uk

Institution

University of Kent

Country

UK

ORCID For Submitting Author

0000-0002-2848-9077

Declaration of Conflict of Interest

We have no conflicts of interest to declare

Version Notes

Second preprint version

Exports