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Protein-Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
preprintrevised on 03.12.2019, 12:18 and posted on 11.12.2019, 11:09 by Caroline Apel, Marc-André Kasper, Christian E. Stieger, Christian P. R. Hackenberger, Mathias Christmann
A new lysine‐reactive cyclopropropyl aldehyde for the covalent modification of proteins was developed. The reagent exploits a divinylcyclopropane‐cycloheptadiene rearrangement to render the initial condensation irreversible. A labelling study on eGFP demonstrated excellent chemoselectivity for the modification of amine‐nucleophiles with the possibility of subsequent modifications.
Read the published paper
in Organic Letters