Protein-Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal

17 November 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A new lysine‐reactive cyclopropropyl aldehyde for the covalent modification of proteins was developed. The reagent exploits a divinylcyclopropane‐cycloheptadiene rearrangement to render the initial condensation irreversible. A labelling study on eGFP demonstrated excellent chemoselectivity for the modification of amine‐nucleophiles with the possibility of subsequent modifications.

Keywords

Protein modification
Cyclopropanes
Lysine modification

Supplementary materials

Title
Description
Actions
Title
TOCPIC
Description
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