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Photochemically-Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

preprint
revised on 17.01.2020 and posted on 21.01.2020 by R. Thomas Simons, Georgia Scott, Anastasia Gant Kanegusuku, Jennifer Roizen
A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverates a dual-catalytic system of nickel and a photoexcitable iridium complex and proceeds at room temperature under visible light irradiation. Using these tactics, aryl boronic esters and aryl chlorides can be carried through the reaction untouched. Thereby, this method complements known Buchwald-Hartwig coupling methods for N-arylation of sulfamides.

Funding

R35GM128741–01

History

Email Address of Submitting Author

j.roizen@duke.edu

Institution

Duke University

Country

United States

ORCID For Submitting Author

0000-0002-6053-5512

Declaration of Conflict of Interest

The authors declare no conflicts of interest.

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in The Journal of Organic Chemistry

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