Photochemically-Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

R. Thomas Simons; Georgia Scott; Anastasia Gant Kanegusuku; Jennifer Roizen

doi:10.26434/chemrxiv.11456118.v1

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Photochemically-Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

31 December 2019, Version 1

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Abstract

A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverates a dual-catalytic system of nickel and a photoexcitable iridium complex and proceeds at room temperature under visible light irradiation. Using these tactics, aryl boronic esters and aryl chlorides can be carried through the reaction untouched. Thereby, this method complements known Buchwald-Hartwig coupling methods for N-arylation of sulfamides.

Keywords

Buchwald-Hartwig amination

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Now Published

Photochemically Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

R. Thomas Simons, Georgia E. Scott, Anastasia Gant Kanegusuku, Jennifer L. Roizen journal article

The Journal of Organic Chemistry , Volume 85, Issue 10

Online publication date: Apr 21, 2020

Version History

Jan 21, 2020 Version 2

Dec 31, 2019 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.11456118.v1

Funding

R35GM128741–01

Author’s competing interest statement

The authors declare no conflicts of interest.

Photochemically-Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

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Author’s competing interest statement

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