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Ultrapermeable Artificial Aquaporins.pdf (2.06 MB)
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Foldamer-Based Ultrapermeable and Highly Selective Artificial Aquaporins that Exclude Protons

preprint
submitted on 25.08.2020 and posted on 26.08.2020 by Arundhati Roy, Jie Shen, Himanshu Joshi, Woochul Song, Yu-Ming Tu, Ye Ruijuan, Ning Li, Changliang Ren, Manish Kumar, Aleksei Aksimentiev, Huaqiang Zeng
The outstanding capacity of aquaporins (AQPs) for mediating highly selective superfast water transport1-7 has inspired recent development of supramolecular monovalent ion-excluding artificial water channels (AWCs). AWC-based bioinspired membranes are proposed for desalination, water purification, and other separations applications8-18. While some recent progress has been made in synthesizing AWCs that approach the water permeability and ion selectivity of AQPs, a hallmark feature of AQPs – high water transport while excluding protons has not been reproduced. We report on a class of biomimetic, helically folded pore-forming polymeric foldamers, that can serve as long sought-after highly selective ultrafast water-conducting channels exceeding those of AQPs (1.1 × 1010 H2O molecules/s for AQP17), with high water over monovalent ion transport selectivity (~108 water molecules over Cl- ion) conferred by the modularly tunable hydrophobicity of the interior pore surface. The best-performing AWC reported here delivers water transport at an exceptionally high rate, 2.5 times that of AQP1, while concurrently rejecting salts (NaCl and KCl) and even protons.

History

Email Address of Submitting Author

hqzeng@nbl.a-star.edu.sg

Institution

NanoBio Lab, A*STAR

Country

Singapore

ORCID For Submitting Author

0000-0002-8246-2000

Declaration of Conflict of Interest

The authors declare that there is no conflict of interest.

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