Photochemically-Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

R. Thomas Simons; Georgia Scott; Anastasia Gant Kanegusuku; Jennifer Roizen

doi:10.26434/chemrxiv.11456118.v2

Catalysis

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Photochemically-Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides

21 January 2020, Version 2

Working Paper

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverates a dual-catalytic system of nickel and a photoexcitable iridium complex and proceeds at room temperature under visible light irradiation. Using these tactics, aryl boronic esters and aryl chlorides can be carried through the reaction untouched. Thereby, this method complements known Buchwald-Hartwig coupling methods for N-arylation of sulfamides.

Keywords

Buchwald-Hartwig amination

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