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6 results in Keywords: sirtuins

Biological and Medicinal Chemistry

Working Paper

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design using Mechanism-based Sirtuin Inhibition

Nima Rajabi, Alexander Lund Nielsen, Christian Adam Olsen

Version 2 posted 03 February 2020

1,022

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Biological and Medicinal Chemistry

Working Paper

Activity-Dependent Probes Containing Epsilon-N-Thioacyllysine and -Epsilon-N-Acyl-(Delta-Aza)lysine Residues

Michael Bæk,, Pablo Martín-Gago, Jonas S. Laursen, Julie L. H. Madsen, Saswati Chakladar, Christian Adam Olsen

Version 1 posted 29 November 2019

621

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Biological and Medicinal Chemistry

Working Paper

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

Daria Monaldi, Dante Rotili, Julien Lancelot, Martin Marek, Nathalie Wössner, Alessia Lucidi, Daniela Tomaselli, Elizabeth Ramos-Morales, Christophe Romier, Raymond J. Pierce, Antonello Mai, Manfred Jung

Version 2 posted 02 August 2019

974

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Biological and Medicinal Chemistry

Review

Chiral Posttranslational Modification to Lysine epsilon-Amino Groups

Carlos Moreno–Yruela, Michael Bæk, Fabrizio Monda, Christian Adam Olsen

Version 1 posted 18 April 2022

332

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Biological and Medicinal Chemistry

Working Paper

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Nima Rajabi, Alexander L. Nielsen, Tobias N. Hansen, Huy T. Nguyen, Michael Bæk, Julie E. Bolding, Oskar Ø. Bahlke, Sylvester E. G. Petersen, Christian R. O. Bartling, Kristian Strømgaard, Christian Adam Olsen

Version 1 posted 24 November 2021

370

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Organic Chemistry

Working Paper

Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Julie E. Bolding, Pablo Martín-Gago, Nima Rajabi, Luke F. Gamon, Tobias N. Hansen, Michael Jonathan Davies, Christian Adam Olsen

Version 1 posted 23 February 2022

463

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6 results in sirtuins in Keywords: sirtuins

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design using Mechanism-based Sirtuin Inhibition

Activity-Dependent Probes Containing Epsilon-N-Thioacyllysine and -Epsilon-N-Acyl-(Delta-Aza)lysine Residues

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

Chiral Posttranslational Modification to Lysine epsilon-Amino Groups

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

6 results in Keywords: sirtuins