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Biological and Medicinal Chemistry

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orexin receptor

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5 results in Keywords: orexin receptor

Biological and Medicinal Chemistry

Design and synthesis of orexin 1 receptor-selective agonists

Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh

Version 1 posted 31 October 2022

654

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Biological and Medicinal Chemistry

Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton

Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase

Version 1 posted 23 November 2021

721

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Biological and Medicinal Chemistry

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library

Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Oshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Emi Hasegawa, Takeshi Sakurai, Yasuo Uchida, Tetsu Sato, Hiroaki Gouda, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase

Version 1 posted 25 October 2021

326

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Biological and Medicinal Chemistry

Structure-guided discovery of orexin receptor-binding PET ligands

Katharina Distler, Simone Maschauer, Eduard Neu, Harald Hübner, Jürgen Einsiedel, Olaf Prante, Peter Gmeiner

Version 1 posted 06 May 2024

146

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Biological and Medicinal Chemistry

Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18F-fluorination of boroxines, in vitro and initial in vivo evaluation

Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin Fromm, Harald Hübner, Peter Gmeiner, Olaf Prante

Version 1 posted 20 May 2024

172

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