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The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline

Giuseppe Faudone, Whitney Kilu, Xiaomin Ni, Apirat Chaikuad, Sridhar Sreeramulu, Pascal Heitel, Harald Schwalbe, Stefan Knapp, Manfred Schubert-Zsilavecz, Jan Heering, Daniel Merk

Version 1 posted 10 May 2021

312

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1

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Analytical Chemistry

Working Paper

Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid-beta M1-42

Priya Prakash, Travis Lantz, Krupal P. Jethava, Gaurav Chopra

Version 1 posted 15 February 2019

537

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Theoretical and Computational Chemistry

Working Paper

N-glycosylation induced changes in tau protein dynamics reveal its role in tau misfolding and aggregation: A microsecond long molecular dynamics study

Alen T Mathew, Anurag TK Baidya, Bhanuranjan Das, Rajnish Kumar

Version 1 posted 19 January 2022

446

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Analytical Chemistry

Working Paper

A coumarin-based array to discriminate between different types of amyloid fibrils

Natalie Trinh, Kaustubh R. Bhuskute, Nikhil R. Varghese, Jessica A. Buchanan, Fiona M. McCutcheon, Robert L. Medcalf, Katrina A. Jolliffe, Margaret Sunde, Elizabeth J. New, Amandeep Kaur

Version 1 posted 26 June 2023

191

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Biological and Medicinal Chemistry

Working Paper

Structural optimization of oxaprozin for selective inverse Nurr1 agonism

Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F. Lillich, Till Kasch, Úrsula López-García, Julian A. Marschner, Lorena A. Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk

Version 1 posted 30 July 2024

99

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Biological and Medicinal Chemistry

Working Paper

Structure-based design of seed-competent proteomimetic macrocycles derived from 4R tauopathic folds

Isaac Angera, Xueyong Xu, Benjamin Rajewski, Grace Hallinan, Bernardino Ghetti, Ruben Vidal, Wen Jiang, Juan Del Valle

Version 1 posted 26 February 2024

467

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Biological and Medicinal Chemistry

Review

Rare diseases, spotlighting amyotrophic lateral sclerosis, Huntington’s disease, and myasthenia gravis: Insights from landscape analysis of current research

Kavita Iyer, Rumiana Tenchov, Janet Sasso, Krittika Ralhan, Jyotsna Jotshi, Dmitrii Polshakov, Ankush Maind, Qiongqiong Angela Zhou

Version 2 posted 12 August 2024

549

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Polymer Science

Working Paper

Biological activity In vitro, absorption, BBB penetration and tolerability of nanoformulation of BT44, a RET agonist with disease-modifying potential for the treatment of neurodegeneration

Malik Salman Haider, Arun Kumar Mahato, Anastasiia Kotliarova, Stefan Forster, Bettina Böttcher, Philipp Stahlhut, Yulia Sidorova, Robert Luxenhofer

Version 2 posted 27 September 2022

439

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8 results in neurodegeneration in Keywords: neurodegeneration

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline

Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid-beta M1-42

N-glycosylation induced changes in tau protein dynamics reveal its role in tau misfolding and aggregation: A microsecond long molecular dynamics study

A coumarin-based array to discriminate between different types of amyloid fibrils

Structural optimization of oxaprozin for selective inverse Nurr1 agonism

Structure-based design of seed-competent proteomimetic macrocycles derived from 4R tauopathic folds

Rare diseases, spotlighting amyotrophic lateral sclerosis, Huntington’s disease, and myasthenia gravis: Insights from landscape analysis of current research

Biological activity In vitro, absorption, BBB penetration and tolerability of nanoformulation of BT44, a RET agonist with disease-modifying potential for the treatment of neurodegeneration

8 results in Keywords: neurodegeneration