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Benchtop 19F nuclear magnetic resonance (NMR) spectroscopy provides mechanistic insight into the Biginelli condensation towards the chemical synthesis of novel trifluorinated dihydro- and tetrahydropyrimidinones as antiproliferative agents

Rosie Chen, Pratyush Singh, Sarah Su, Selin Kocalar, Xina Wang, Neha Mandava, Srishti Venkatesan, Adrienne Ferguson, Aishi Rao, Emma Le, Casey Rojas, Edward Njoo

Version 2 posted 07 December 2022

306

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Organic Chemistry

Working Paper

Chemoenzymatic Multicomponent Synthesis of Nirmatrelvir

Hans Daniel Preschel, Ruben T. Otte, Ying Zhuo, Rebecca E. Ruscoe, Ashleigh J. Burke, Rachel Cowan, Brendan Horst, Sven Hennig, Elwin Janssen, Anthony Green, Nicholas J. Turner, Eelco Ruijter

Version 1 posted 27 June 2022

1,093

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2

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Catalysis

Working Paper

Photocatalytic selective 1,2-hydroxyacylmethylation of 1,3-dienes with sulfur ylides as source of alkyl radicals

Shuang-Hua Xu, Dong-Mei Yan, Li Rao, Min Jiang, Ya-Li Wu, Wen-Jing Xiao, Jia-Rong Chen

Version 1 posted 24 February 2022

589

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Organic Chemistry

Working Paper

The Ugi-Smiles Reaction on Steroids: Discovery of Bioactive N,N-Disubstituted 3- Aminoestrones

Cecilia Attorresi, Bruno Falcone, Evelyn Bonifazi, Gabriel Gola, Andrea Barquero, Javier Alberto Ramirez

Version 1 posted 07 September 2020

447

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Biological and Medicinal Chemistry

Working Paper

A Reliable and Sustainable Multicomponent Access to Protein Degraders

Irene Preet Bhela, Alice Ranza, Marta Serafini, Tracey PIRALI

Version 2 posted 25 October 2021

1,539

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Organic Chemistry

Working Paper

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

Benjamin Lipp, Lisa Marie Kammer, Murat Kucukdisli, Adriana Luque, Jonas Kühlborn, Stefan Pusch, Gita Matulevičiūtė, Dieter Schollmeyer, Algirdas Šačkus, Till Opatz

Version 1 posted 15 February 2019

3,509

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Catalysis

Working Paper

A Photoredox-Catalyzed Four Component Reaction for the Atom-Efficient Synthesis of Complex Secondary Amines

Lisa Marie Kammer, Matthias Krumb, Benjamin Spitzbarth, Benjamin Lipp, Jonas Kühlborn, Jonas Busold, Olga Mulina, Alexander O. Terent’ev, Till Opatz

Version 1 posted 07 February 2020

826

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Catalysis

Working Paper

The Role of Xantphos in forming an Elusive dirhodium-η1-allyl Intermediate in a Rh(II)-Catalyzed Allylic Alkylation: A Combined Computational and Experimental Study

Anubhav Goswami, Romin Gogoi, Arpita Panda, Aakash Chandresh Sheth, Garima Jindal

Version 2 posted 30 May 2023

382

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Organic Chemistry

Working Paper

Investigating Multicomponent Approaches for the Site-Selective Conjugation of Native Proteins

Charlotte Sornay, Steve Hessmann, Stéphane Erb, Igor Dovgan, Anthony Ehkirch, Thomas Botzanowski, Sarah Cianferani, Alain Wagner, Guilhem Chaubet

Version 1 posted 12 March 2020

922

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9 results in multicomponent reactions in Keywords: multicomponent reactions

Benchtop 19F nuclear magnetic resonance (NMR) spectroscopy provides mechanistic insight into the Biginelli condensation towards the chemical synthesis of novel trifluorinated dihydro- and tetrahydropyrimidinones as antiproliferative agents

Chemoenzymatic Multicomponent Synthesis of Nirmatrelvir

Photocatalytic selective 1,2-hydroxyacylmethylation of 1,3-dienes with sulfur ylides as source of alkyl radicals

The Ugi-Smiles Reaction on Steroids: Discovery of Bioactive N,N-Disubstituted 3- Aminoestrones

A Reliable and Sustainable Multicomponent Access to Protein Degraders

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

A Photoredox-Catalyzed Four Component Reaction for the Atom-Efficient Synthesis of Complex Secondary Amines

The Role of Xantphos in forming an Elusive dirhodium-η1-allyl Intermediate in a Rh(II)-Catalyzed Allylic Alkylation: A Combined Computational and Experimental Study

Investigating Multicomponent Approaches for the Site-Selective Conjugation of Native Proteins

9 results in Keywords: multicomponent reactions