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Discovery of fully synthetic FKBP12-mTOR molecular glues

Robin C.E. Deutscher, Christian Meyners, Maximilian L. Repity, Wisely Oki Sugiarto, Jürgen Kolos, Edvaldo Maciel, Tim Heymann, Thomas M. Geiger, Stefan Knapp, Frederik Lermyte, Felix Hausch

Version 2 posted 02 July 2024

2,885

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Biological and Medicinal Chemistry

Working Paper

Scoring Methods in Lead Optimization of Molecular Glues

Lei Jia, Dahlia Weiss, Benjamin Shields, Brian Claus, Veerabahu Shanmugasundaram, Stephen Johnson, Jennifer Riggs, Christoph Zapf

Version 3 posted 17 January 2024

1,377

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Biological and Medicinal Chemistry

Working Paper

A method to identify small molecule/protein pairs susceptible to protein ubiquitination

Pinwen Cai, Basilius Sauter, Saule Zhanybekova, Dennis Gillingham

Version 1 posted 22 April 2024

609

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Analytical Chemistry

Working Paper

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Irene Ponzo, Alice Solda, Charlotte Crowe, Goran Dahl, Stefan Geschwindner, Alessio Ciulli, Ulrich Rant

Version 1 posted 06 March 2024

1,913

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Organic Chemistry

Working Paper

Concise synthesis of (–)-cotylenol, a 14-3-3 PPI molecular glue

Tucker Huffman, Akihiro Kuroo, Ryota Sato, Ryan Shenvi

Version 1 posted 28 September 2022

2,452

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2

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Biological and Medicinal Chemistry

Review

Rational Design of Molecular Glues: Breakthroughs and Perspectives

Juzeng An, Xiaojun Zhang

Version 2 posted 02 January 2024

1,070

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Biological and Medicinal Chemistry

Working Paper

A system for the evolution of protein-protein interaction inducers

Jeffrey Dewey, Saara-Anne Azizi, Vivian Lu, Bryan Dickinson

Version 1 posted 22 June 2021

874

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Theoretical and Computational Chemistry

Working Paper

Molecular dynamics approach for capturing calixarenes--proteins interactions: the case of cytochrome c

Alessio Bartocci, florence szczepaniak, Tao Jiang, Natacha Gillet, Elise Dumont

Version 2 posted 17 September 2020

924

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Materials Chemistry

Working Paper

A Dissipative Supramolecular Glue for Temporal Control of Amplified Enzyme Activity and Biocatalytic Cascades

Alisha Kamra, Sourav Das, Preeti Bhatt, Manju Solra, Tanmoy Maity, Subinoy Rana

Version 1 posted 14 November 2022

454

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1

Citations

Biological and Medicinal Chemistry

Review

Molecular glues: The adhesive connecting targeted protein degradation to the clinic

Janet M. Sasso, Rumiana Tenchov, DaSheng Wang, Linda S. Johnson, Xinmei Wang, Qiongqiong Angela Zhou

Version 1 posted 16 June 2022

4,296

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1

Citations

Refine Search

10 results in molecular glue in Keywords: molecular glue

Discovery of fully synthetic FKBP12-mTOR molecular glues

Scoring Methods in Lead Optimization of Molecular Glues

A method to identify small molecule/protein pairs susceptible to protein ubiquitination

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Concise synthesis of (–)-cotylenol, a 14-3-3 PPI molecular glue

Rational Design of Molecular Glues: Breakthroughs and Perspectives

A system for the evolution of protein-protein interaction inducers

Molecular dynamics approach for capturing calixarenes--proteins interactions: the case of cytochrome c

A Dissipative Supramolecular Glue for Temporal Control of Amplified Enzyme Activity and Biocatalytic Cascades

Molecular glues: The adhesive connecting targeted protein degradation to the clinic

10 results in Keywords: molecular glue