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Towards a RIOK2 Chemical Probe: Cellular Potency Improvement of a Selective 2-(Acylamino)pyridine Series

Christopher Wang, Álvaro Lorente-Macías, Carrow Wells, Julie E. Pickett, Alfredo Picado, William Zuercher, Alison Axtman

Version 1 posted 17 August 2020

225

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Organic Chemistry

Working Paper

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Carrow Wells, David Drewry, Julie E. Pickett, Alison D. Axtman

Version 2 posted 18 May 2020

917

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1

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Biological and Medicinal Chemistry

Working Paper

Development of Potent and Selective PfCLK3 Inhibitors Based on GSK-TCMDC151 as a New Class of Antimalarials

Amit Mahindra, Omar Janha, Kopano Mapesa, Ana Sanchez-Azqueta, Mahmood M. Alam, Andrew Tobin, Andrew Jamieson

Version 1 posted 13 September 2019

804

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Organic Chemistry

Working Paper

Concise, Gram-Scale Synthesis of Furo[2,3-B]pyridines, with Functional Handles for Chemoselective Cross-Coupling

Sean O'Byrne, Benjamin J. Eduful, Timothy M. Willson, David Drewry

Version 1 posted 17 March 2020

565

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Biological and Medicinal Chemistry

Working Paper

How Reactive are Druggable Cysteines in Protein Kinases?

Ernest Awoonor-Williams, Christopher Rowley

Version 1 posted 10 October 2017

1,200

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Biological and Medicinal Chemistry

Working Paper

Synthesis of a Novel Pyrano[2,3-C]pyrazole Enabling PKBβ/AKT2 Inhibitory and in Vitro Anti-Glioma Activity

Ruturajsinh M. Vala, Vasudha Tandon, Lynden G Nicely, Luxia Guo, Yanlong Gu, Sourav Banerjee, Hitendra M Patel

Version 1 posted 14 June 2021

410

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4

Citations

Biological and Medicinal Chemistry

Working Paper

Predicting resistance to small molecule kinase inhibitors

Anu Nagarajan, Katherine Amberg-Johnson, Evan Paull, Kunling Huang, Phani Ghanakota, Asela Chandrasinghe, Jackson Chief Elk, Jared M. Sampson, Lingle Wang, Robert Abel, Steven K. Albanese

Version 1 posted 15 November 2024

109

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Biological and Medicinal Chemistry

Working Paper

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

Han Wee Ong, Xuan Yang, Jeffery Smith, Rebekah Dickmander, Jason Brown, Tammy Havener, Sharon Taft-Benz, Stefanie Howell, Marcia Sanders, Jacob Capener, Rafael Couñago, Edcon Chang, Andreas Krämer, Nathaniel Moorman, Mark Heise, Alison Axtman, David Drewry, Timothy Willson

Version 1 posted 24 April 2024

199

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Theoretical and Computational Chemistry

Working Paper

KiSSim: Predicting off-targets from structural similarities in the kinome

Dominique Sydow, Eva Aßmann, Albert J. Kooistra, Friedrich Rippmann, Andrea Volkamer

Version 1 posted 16 December 2021

492

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Theoretical and Computational Chemistry

Working Paper

Accelerating Alchemical Free Energy Prediction Using a Multistate Method: Application to Multiple Kinases

Candide Champion, René Gall, Benjamin Ries, Salomé R. Rieder, Emilia P. Barros, Sereina Riniker

Version 2 posted 14 September 2023

390

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28 results in kinase in Keywords: kinase

Towards a RIOK2 Chemical Probe: Cellular Potency Improvement of a Selective 2-(Acylamino)pyridine Series

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Development of Potent and Selective PfCLK3 Inhibitors Based on GSK-TCMDC151 as a New Class of Antimalarials

Concise, Gram-Scale Synthesis of Furo[2,3-B]pyridines, with Functional Handles for Chemoselective Cross-Coupling

How Reactive are Druggable Cysteines in Protein Kinases?

Synthesis of a Novel Pyrano[2,3-C]pyrazole Enabling PKBβ/AKT2 Inhibitory and in Vitro Anti-Glioma Activity

Predicting resistance to small molecule kinase inhibitors

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

KiSSim: Predicting off-targets from structural similarities in the kinome

Accelerating Alchemical Free Energy Prediction Using a Multistate Method: Application to Multiple Kinases

28 results in Keywords: kinase