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5 results in Keywords: high-throughput synthesis

Biological and Medicinal Chemistry

Rapid PROTAC discovery platform: nanomole scale array synthesis and direct screening of reaction mixtures to facilitate the expedited discovery and follow-up of PROTAC hits.

Mateusz Plesniak, Emilia K. Taylor, Frederik Eisele, Christopher M. B. K. Kourra, Iacovos Michaelides, Alice Oram, Johan Wernevik, Zulma Santisteban-Valencia, Hannah Rowbottom, Nadia Mann, Linda Fredlund, Valentyna Pivnytska, Anna Noven, Mohammad Pirmoradian, Thomas Lundback, R. Ian Storer, Mariell Pettersson, Gian Marco De Donatis, Marie Rehnstrom

Version 1 posted 18 July 2023

2,266

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1

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Biological and Medicinal Chemistry

Efficient large-scale exploration of fragment hit progression by exploiting binding-site purification of actives (B-SPA) through combining multi-step array synthesis and HT crystallography.

Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson, Lizbé Koekemoer, James Bennett, Cameron Anderson, Conor Wild, William Bradshaw, Edward A FitzGerald, Tobias Krojer, Anthony Bradley, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank von Delft

Version 2 posted 09 February 2024

1,070

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Materials Chemistry

Understanding the Ligand-Assisted Reprecipitation of CsPbBr3 Perovskite Nanocrystals via High Throughput Robotic Synthesis Approach

Sheryl L. Sanchez, Jonghee Yang, Mahshid Ahmadi

Version 1 posted 09 February 2023

863

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2

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Biological and Medicinal Chemistry

Acetoxymethyl-BODIPY Dyes: A Universal Platform for the Fluorescence Labeling of Nucleophiles

Alberto Blazquez-Moraleja, Larissa Maierhofer, Enrique Mann, Ruth Prieto-Montero, Ainhoa Oliden-Sanchez, Lucia Celada, Virginia Martinez-Martinez, Maria-Dolores Chiara, Jose Luis Chiara

Version 2 posted 06 July 2022

445

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Theoretical and Computational Chemistry

Path Toward High-Throughput Synthesis Planning via Performance Benchmarking

Brandon Walker, Nathan Miller, Brett Yang, Dhatri V. L. Penna, Sridhar Vuyyuru, Jeyaraman Soundararajan, Ilia Vorontcov, Andrew Girvin, Amin Mannaa, Maya Choudhury, Hailey Fox, Mihir Bafna, Eduardo Luiggi Lopez, Hugo Hernandez, Jennifer King, Thierry Masquelin, Samuel G. Michael, Alexander G. Godfrey, Gergely Zahoránszky-Kőhalmi

Version 1 posted 12 August 2024

188

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