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5 results in Keywords: egfr

Biological and Medicinal Chemistry

Molecular Design of a “Two-in-One” Orthosteric-Allosteric Chimeric Mutant Selective EGFR Inhibitor

Florian Wittlinger, David E. Heppner, Ciric To, Marcel Guenther, Bo Hee Shin, Jaimin K. Rana, Anna M. Schmoker, Tyler S. Beyett, Pasi A. Jänne, Michael J. Eck, Stefan Laufer

Version 1 posted 21 December 2020

922

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Theoretical and Computational Chemistry

Actives-Based Receptor Selection Strongly Increases Success Rate in Structure-Based Drug Design and Leads to Identification of 22 Unique Potent Cancer Inhibitors

Eric R. Hantz, Steffen Lindert

Version 1 posted 24 January 2022

239

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1

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Biological and Medicinal Chemistry

Use of Marine biotoxins to modulate the tyrosine kinase domain of the human epidermal growth factor receptor

Charli Deepak Arulanandam, Ramesh Dharmara, Prathiviraj Ragothaman, Samuel Gnana Prakash Vincent

Version 1 posted 01 November 2021

189

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1

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Biological and Medicinal Chemistry

Rational Design and Synthesis of Novel Dual Protacs for Simultaneous Degradation of EGFR and PARP

Mengzhu Zheng, Junfeng Huo, Xiaoxia Gu, Canrong Wu, Qingzhe Zhang, Wang Wang, Yang Liu, Yu Liu, Xuechen Zhou, Lixia Chen, Yirong Zhou, Hua Li

Version 1 posted 18 February 2021

945

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Biological and Medicinal Chemistry

Developing Chlorin/Arylaminoquinazoline Conjugates with Nanomolar Activity for Targeted Photodynamic Therapy: Design, Synthesis, SAR, and Biological Evaluation

Lubov V. Krylova, Vasilii F. Otvagin, Galina P. Gribova, Natalia S. Kuzmina, Ekaterina A. Fedotova, Ivan V. Zelepukin, Alexander V. Nyuchev, Irina V. Balalaeva, Alexey Yu. Fedorov

Version 1 posted 01 July 2024

109

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