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Biocatalytic Synthesis of a Key Chiral Delamanid Precursor using an Engineered P450 Monooxygenase

Nicholas Turner, Georgia Harris, Christopher Taylor, William Finnigan, Fei Zhao, Grayson Ford, Amy Hutton, Ian Rowles, Anthony Green

Version 1 posted 22 November 2024

350

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Materials Science

Working Paper

Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins

Seunghyeon Kim, Emma H. Yee, Eric A. Miller, Yining Hao, Dousabel M. Y. Tay, Ki-Joo Sung, Huan Jia, Joseph M. Johnson, Mohsan Saeed, Charles R. Mace, Deniz Yüksel Yurt, Hadley Sikes

Version 1 posted 19 April 2021

873

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Biological and Medicinal Chemistry

Working Paper

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors

Nathaniel Goldberg, Anders M. Knight, Ruijie Zhang, Frances H. Arnold

Version 1 posted 05 November 2019

1,193

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Biological and Medicinal Chemistry

Working Paper

Straightforward Background Depletion Unlocks Transaminase Evolution Through Solid-Phase Screening

Matteo Planchestainer, Eimear Hegarty, Christian Heckmann, Louise Gourlay, Francesca Paradisi

Version 1 posted 25 March 2019

531

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Catalysis

Working Paper

In Vivo Assembly of Artificial Metalloenzymes and Application in Whole‐Cell Biocatalysis

Shreyans Chordia, Siddarth Narasimhan, Alessandra Lucini Paioni, Marc Baldus, Gerard Roelfes

Version 1 posted 17 June 2020

795

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Catalysis

Working Paper

Engineering Protein Dynamics of Ancestral Luciferase

Andrea Schenkmayerova, Gaspar Pinto, Martin Toul, Martin Marek, Lenka Hernychova, Joan Planas-Iglesias, Veronika Liskova, Daniel Pluskal, Michal Vasina, Stephane Emond, Mark Doerr, Radka Chaloupková, David Bednar, Zbynek Prokop, Florian Hollfelder, Uwe T. Bornscheuer, Jiri Damborsky

Version 1 posted 17 August 2020

392

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1

Citations

Catalysis

Working Paper

Directed Evolution of an Feᴵᴵ-Dependent Halogenase for Asymmetric C(sp³)-H Chlorination

Sabine Duewel, Luca Schmermund, Tabea Faber, Klaus Harms, Vasundara Srinivasan, Eric Meggers, Sabrina Hoebenreich

Version 1 posted 05 November 2019

903

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Catalysis

Working Paper

Biocatalytic Conversion of 5-Hydroxymethylfurfural by Galactose Oxidase: Toward Scalable Technology Using Integrated Process and Enzyme Engineering

William Birmingham, Asbjørn Toftgaard Pedersen, Mafalda Dias Gomes, Mathias Bøje Madsen, Michael Breuer, John Woodley, Nicholas J. Turner

Version 1 posted 08 September 2020

619

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2

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Catalysis

Working Paper

A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons

Xiongyi Huang, Marc Garcia-Borràs, Kun Miao, S. B. Jennifer Kan, Arjun Zutshi, K. N. Houk, Frances H. Arnold

Version 1 posted 26 September 2018

1,430

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Analytical Chemistry

Working Paper

Development of 96 Multiple Injection-GC-MS Technique and Its Application in Protein Engineering of Natural and Non-Natural Enzymatic Reactions

Anja Knorrscheidt, Pascal Püllmann, Eugen Schell, Dominik Homann, Erik Freier, Martin Weissenborn

Version 1 posted 03 December 2019

941

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1

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Refine Search

47 results in directed evolution in Keywords: directed evolution

Biocatalytic Synthesis of a Key Chiral Delamanid Precursor using an Engineered P450 Monooxygenase

Developing a SARS-CoV-2 Antigen Test Using Engineered Affinity Proteins

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors

Straightforward Background Depletion Unlocks Transaminase Evolution Through Solid-Phase Screening

In Vivo Assembly of Artificial Metalloenzymes and Application in Whole‐Cell Biocatalysis

Engineering Protein Dynamics of Ancestral Luciferase

Directed Evolution of an Feᴵᴵ-Dependent Halogenase for Asymmetric C(sp³)-H Chlorination

Biocatalytic Conversion of 5-Hydroxymethylfurfural by Galactose Oxidase: Toward Scalable Technology Using Integrated Process and Enzyme Engineering

A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons

Development of 96 Multiple Injection-GC-MS Technique and Its Application in Protein Engineering of Natural and Non-Natural Enzymatic Reactions

47 results in Keywords: directed evolution