Search

14 results in Keywords: covalent inhibitor

Biological and Medicinal Chemistry

Working Paper

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

John Eaton, Richard A. Ruberto, Anneke Kramm, Vasanthi S. Viswanathan, Stuart Schreiber

Version 1 posted 23 January 2019

852

Downloads

Biological and Medicinal Chemistry

Working Paper

Targeted Covalent Inhibition of Telomerase

Rick Betori, Yue Liu, Ding Wu, Rama Mishra, Scott Cohen, Stephen J. Kron, Karl Scheidt

Version 1 posted 23 July 2019

925

Downloads

Biological and Medicinal Chemistry

Working Paper

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Lei Wang, Louis Riel, Bekim Bajrami, Bin Deng, Amy Howell, Xudong Yao

Version 2 posted 13 April 2020

828

Downloads

Biological and Medicinal Chemistry

Working Paper

Structure–activity Relationships of Glutathione Peroxidase 4 Inhibitor Warheads

John Eaton, Laura Furst, Luke Cai, Vasanthi S. Viswanathan, Stuart L. Schreiber

Version 1 posted 20 April 2020

892

Downloads

Biological and Medicinal Chemistry

Working Paper

Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment

Andrew Jamieson, Skye Brettell, Omar Jahna, Abbey Begen, Gillian Cann, Niniola Olaniyan, Saumya Sharma, Tamas Yelland, Alison Hole, Benazir Alam, Ross Gillespie, Michael Capper, Graeme Milligan, David Clarke, Andrew Tobin

Version 1 posted 21 May 2024

387

Downloads

Biological and Medicinal Chemistry

Working Paper

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Qinheng Zheng, Jordan L. Woehl, Seiya Kitamura, Diogo Santos-Martins, Christopher J. Smedley, Gencheng Li, Stefano Forli, John E. Moses, Dennis W. Wolan, K. Barry Sharpless

Version 1 posted 15 March 2019

1,665

Downloads

Citations

Organic Chemistry

Working Paper

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless

Version 1 posted 25 April 2022

645

Downloads

Biological and Medicinal Chemistry

Working Paper

Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of Beta-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors

Anirban Ghoshal, Álvaro Magalhães, Kesatebrhan Asressu, Mohammad Hossain, Matthew Todd, Timothy Willson

Version 1 posted 30 April 2024

161

Downloads

Biological and Medicinal Chemistry

Working Paper

Pitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors

Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner

Version 1 posted 24 August 2023

403

Downloads

Biological and Medicinal Chemistry

Working Paper

Telomerase Reverse Transcriptase Degradation via a Rationally Designed Covalent Proteolysis Targeting Chimera

Grant Frost, Yue Liu, Stephen Kron, Karl Scheidt

Version 3 posted 27 June 2024

360

Downloads

Search

Refine Search

14 results in covalent inhibitor in Keywords: covalent inhibitor

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

Targeted Covalent Inhibition of Telomerase

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Structure–activity Relationships of Glutathione Peroxidase 4 Inhibitor Warheads

Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of Beta-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors

Pitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors

Telomerase Reverse Transcriptase Degradation via a Rationally Designed Covalent Proteolysis Targeting Chimera

14 results in Keywords: covalent inhibitor