Search

Biological and Medicinal Chemistry

Working Paper

Computer-aided design, synthesis, and biological evaluation of [4.3.0] bicyclic prolyl oligopeptidase and fibroblast activation protein-α dual inhibitors

Nicolas Moitessier, Jessica Plescia, Damien Hedou, Maud Pousse, Anne Labarre, Caroline Dufresne, Anthony Mittermaier

Version 1 posted 30 August 2021

378

Downloads

Biological and Medicinal Chemistry

Working Paper

A Steady-State Algebraic Model for the Time Course of Covalent Enzyme Inhibition

Petr Kuzmic

Version 3 posted 06 August 2020

780

Downloads

Analytical Chemistry

Working Paper

A Novel High-Throughput FLIPR Tetra Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug Discovery

Puneet Khurana, Lisa McWilliams, Jonathan Wingfield, Derek Barratt, Bharath Srinivasan

Version 1 posted 09 December 2020

350

Downloads

Biological and Medicinal Chemistry

Working Paper

Deciding Between One-Step and Two-Step Irreversible Inhibition Mechanisms on the Basis of “Kobs” Data: A Statistical Approach

Petr Kuzmic

Version 2 posted 06 August 2020

1,165

Downloads

Biological and Medicinal Chemistry

Working Paper

Mapping the chemical space of active-site targeted covalent ligands for protein tyrosine phosphatases

Suk ho Hong, Sarah Y Xi, Andrew C Johns, Lauren C Tang, Allyson Li, Madeleine N Hum, Cassandra A Chartier, Marko Jovanovic, Neel H Shah

Version 2 posted 06 March 2023

741

Downloads

Physical Chemistry

Working Paper

Protein electric fields enable faster and longer-lasting covalent inhibition of beta-lactamases

Zhe Ji, Jacek Kozuch, Irimpan Mathews, Christian Diercks, Yasmin Shamsudin, Mirjam Schulz, Steven Boxer

Version 1 posted 22 September 2022

210

Downloads

Biological and Medicinal Chemistry

Working Paper

Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

Nathalie M. Grob, Clint Remarcik, Simon L. Rössler, Jeffrey Y. K. Wong, John C. K. Wang, Jason Tao, Corey L. Smith, Andrei Loas, Stephen L. Buchwald, Dan L. Eaton, Magdalena Preciado López, Bradley L. Pentelute

Version 1 posted 19 June 2023

1,095

Downloads

1

Citations

Biological and Medicinal Chemistry

Working Paper

Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets

Ivy Guan, Joanna Liu, Renata Sawyer, Xiang Li, Wanting Jiao, Yannasittha Jiramongkol, Mark White, Lejla Hagimola, Freda Passam, Denise Tran, Xiaoming Liu, Simone Schoenwaelder, Shaun Jackson, Richard Payne, Xuyu Liu

Version 1 posted 04 July 2023

194

Downloads

Theoretical and Computational Chemistry

Working Paper

Quantum Chemical Methods for Modeling Covalent Modification of Biological Thiols

Ernest Awoonor-Williams, William Isley, Stephen Dale, Erin Johnson, Haibo Yu, Axel Becke, Benoît Roux, Christopher Rowley

Version 2 posted 25 July 2019

962

Downloads

1

Citations

Refine Search

9 results in covalent inhibition in Keywords: covalent inhibition

Computer-aided design, synthesis, and biological evaluation of [4.3.0] bicyclic prolyl oligopeptidase and fibroblast activation protein-α dual inhibitors

A Steady-State Algebraic Model for the Time Course of Covalent Enzyme Inhibition

A Novel High-Throughput FLIPR Tetra Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug Discovery

Deciding Between One-Step and Two-Step Irreversible Inhibition Mechanisms on the Basis of “Kobs” Data: A Statistical Approach

Mapping the chemical space of active-site targeted covalent ligands for protein tyrosine phosphatases

Protein electric fields enable faster and longer-lasting covalent inhibition of beta-lactamases

Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets

Quantum Chemical Methods for Modeling Covalent Modification of Biological Thiols

9 results in Keywords: covalent inhibition