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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Wei Shi, Guanghui Zong, Zhijian Hu, Sarah O’Keefe, Dale Tranter, Ludivine Baron, Michael Iannotti, Belinda Hall, Katherine Corfield, Anja Paatero, Mark Henderson, Peristera Roboti, Jianhong Zhou, Xianwei Sun, Mugunthan Govindarajan, Jason M. Rohde, Nicolas Blanchard, Rachel Simmonds, James Inglese, Yuchun Du, Caroline Demangel, Stephen High, Ville Paavilainen

Version 1 posted 14 January 2019

682

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Analytical Chemistry

Working Paper

An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome

Fangxu Sun, Suttipong Suttapitugsakul, Ronghu Wu

Version 1 posted 10 May 2021

306

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Biological and Medicinal Chemistry

Working Paper

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

Melissa D’Ascenzio, Kathryn Pugh, Rebecca Konietzny, Georgina Berridge, Cynthia Tallant, Shaima Hashem, Octovia P. Monteiro, Jason R. Thomas, Markus Schirle, Stefan Knapp, Brian D. Marsden, Oleg Fedorov, Chas Bountra, Benedikt M. Kessler, Paul E. Brennan

Version 1 posted 17 October 2018

502

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Analytical Chemistry

Working Paper

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors B-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Crosslinking with Michael Acceptor Motif-Containing Drugs

Jennifer Ward, Adán Pinto-Fernández, LoÏc Cornelissen, Sarah Bonham, Laura Diaz Saez, Olivier Riant, Kilian Huber, Benedikt M. Kessler, Olivier Feron, Edward W. Tate

Version 1 posted 25 October 2019

676

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1

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Biological and Medicinal Chemistry

Working Paper

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Lei Wang, Louis Riel, Bekim Bajrami, Bin Deng, Amy Howell, Xudong Yao

Version 2 posted 13 April 2020

828

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Biological and Medicinal Chemistry

Working Paper

Chemical Proteomics-based Target Prioritization through a Residue Agnostic Ligandability Assessment Platform

Fettah Erdogan, Raiyan Chowdhury, Serap Beldar, Tom Bobby Chandy, Rebecca G. Allan, Elvin D. de Araujo, Patrick T. Gunning

Version 1 posted 29 December 2023

487

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Biological and Medicinal Chemistry

Working Paper

Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity

Till Reinhardt, Nina C. Bach, Alex Rothemann, Adrian T. Jauch, Yassmine El Harraoui, Sigrid Müller-Deubert, Martin F. Köllen, Timo Risch, Lianne H.C. Jacobs, Rolf Müller, Franziska R. Traube, Denitsa Docheva, Stefan Zahler, Jan Riemer, Stephan A. Sieber

Version 2 posted 22 October 2024

221

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Biological and Medicinal Chemistry

Working Paper

Chemoproteomics-Enabled De Novo Discovery of Metallothionein Degraders Facilitates Probing Its Role in Cancer

Brittney Racioppo, Dany Pechalrieu, Daniel Abegg, Brendan Dwyer, Neal Ramseier, Ying Hu, Alexander Adibekian

Version 2 posted 13 August 2024

562

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Biological and Medicinal Chemistry

Working Paper

Biomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Phloroglucinol Meroterpenoids

Amy Bracken, Colby Gekko, Nina Suss, Emma Lueders, Qi Cui, Qin Fu, Elizabeth Anderson, Sheng Zhang, Mikail Abbasov

Version 1 posted 29 September 2023

1,055

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Biological and Medicinal Chemistry

Working Paper

Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs

Benjamin Cravatt, Yujia Wang, melissa dix, jarrett remsberg, hsin-yu lee, marian kalocsay, steven gygi, gregory vite, michael lawrence, Christopher Parker

Version 1 posted 27 February 2019

3,402

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1

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Refine Search

16 results in chemical proteomics in Keywords: chemical proteomics

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors B-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Crosslinking with Michael Acceptor Motif-Containing Drugs

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Chemical Proteomics-based Target Prioritization through a Residue Agnostic Ligandability Assessment Platform

Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity

Chemoproteomics-Enabled De Novo Discovery of Metallothionein Degraders Facilitates Probing Its Role in Cancer

Biomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Phloroglucinol Meroterpenoids

Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs

16 results in Keywords: chemical proteomics