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10 results in Keywords: bromodomain

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz

Version 1 posted 23 April 2020

565

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Biological and Medicinal Chemistry

Working Paper

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma Cruzi

Corentine Laurin, Joseph Bluck, Anthony Chan, Michelle Keller, Andrew Boczek, Amy Scorah, K. F. Larissa See, Laura Jennings, David Hewings, Fern Woodhouse, Matthias Schiedel, Philip Humphreys, Philip Biggin, Stuart Conway

Version 1 posted 03 September 2020

577

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Biological and Medicinal Chemistry

Working Paper

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain

Michael Brand, James Clayton, Mustafa Moroglu, Matthias Schiedel, Sarah Picaud, Joseph Bluck, Anna Skwarska, Anthony Chan, Corentine Laurin, Amy Scorah, Larissa See, Timothy Rooney, Oleg Fedorov, Gabriella Perell, Prakriti Kalra, Wilian Cortopassi, Kirsten Christensen, Richard Cooper, Robert Paton, William Pomerantz, Philip Biggin, Ester M. Hammond, Panagis Filippakopoulos, Stuart Conway

Version 1 posted 06 April 2020

617

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Citations

Biological and Medicinal Chemistry

Working Paper

Small molecule ligands of the BET-like bromodomain, SmBRD3, affect Schistosoma mansoni survival, oviposition, and development

Matthias Schiedel, Darius McArdle, Gilda Padalino, Anthony Chan, Josephine Forde-Thomas, Michael McDonough, Helen Whiteland, Manfred Beckmann, Rosa Cookson, Karl Hoffmann, Stuart Conway

Version 1 posted 26 June 2023

225

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Biological and Medicinal Chemistry

Working Paper

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

Melissa D’Ascenzio, Kathryn Pugh, Rebecca Konietzny, Georgina Berridge, Cynthia Tallant, Shaima Hashem, Octovia P. Monteiro, Jason R. Thomas, Markus Schirle, Stefan Knapp, Brian D. Marsden, Oleg Fedorov, Chas Bountra, Benedikt M. Kessler, Paul E. Brennan

Version 1 posted 17 October 2018

502

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Biological and Medicinal Chemistry

Working Paper

A nonequilibrium alchemical method for drug-receptor absolute binding free energy calculations: the role of restraints

Maurice Karrenbrock, Piero Procacci, Francesco Luigi Gervasio

Version 1 posted 28 February 2023

624

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Biological and Medicinal Chemistry

Working Paper

Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes

Huda Zahid, Jeff Costello, Jennifer Kimbrough, Marisa Actis, Zoran Rankovic, William Pomerantz

Version 1 posted 05 October 2022

459

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Biological and Medicinal Chemistry

Working Paper

Rational design and development of selective BRD7 bromodomain inhibitors and their activity in prostate cancer

Sandra Ordonez, Chad Maschinot, Sijie Wang, Surbhi Sood, Brayden Strohmier, Alexander McQuade, Brian Smith, Emily Dykhuizen

Version 1 posted 13 April 2023

332

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Biological and Medicinal Chemistry

Working Paper

Efficient large-scale exploration of fragment hit progression by exploiting binding-site purification of actives (B-SPA) through combining multi-step array synthesis and HT crystallography.

Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson, Lizbé Koekemoer, James Bennett, Cameron Anderson, Conor Wild, William Bradshaw, Edward A FitzGerald, Tobias Krojer, Anthony Bradley, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank von Delft

Version 2 posted 09 February 2024

1,071

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Analytical Chemistry

Working Paper

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Irene Ponzo, Alice Solda, Charlotte Crowe, Goran Dahl, Stefan Geschwindner, Alessio Ciulli, Ulrich Rant

Version 1 posted 06 March 2024

1,919

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10 results in bromodomain in Keywords: bromodomain

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma Cruzi

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain

Small molecule ligands of the BET-like bromodomain, SmBRD3, affect Schistosoma mansoni survival, oviposition, and development

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

A nonequilibrium alchemical method for drug-receptor absolute binding free energy calculations: the role of restraints

Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes

Rational design and development of selective BRD7 bromodomain inhibitors and their activity in prostate cancer

Efficient large-scale exploration of fragment hit progression by exploiting binding-site purification of actives (B-SPA) through combining multi-step array synthesis and HT crystallography.

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

10 results in Keywords: bromodomain