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Biological and Medicinal Chemistry

Working Paper

PHOTACs Enable Optical Control of Protein Degradation

Martin Reynders, Bryan Matsuura, Marleen Bérouti, Daniele Simoneschi, Antonio Marzio, Michele Pagano, Dirk Trauner

Version 2 posted 31 May 2019

3,312

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5

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Biological and Medicinal Chemistry

Working Paper

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Whitney L. Petrilli, Gregory Adam, Roman S. Erdmann, Pravien Abeywickrema, Viju Agnani, Xi Ai, Jen Baysarowich, Noel Byrne, John Caldwell, Wonsuk Chang, Edward DiNunzio, Zhe Feng, Rachel Ford, Sookhee Ha, Yongcheng Huang, Brian Hubbard, Jennifer M. Johnston, Michael Kavana, Jean-Marie Lisnock, Rui Liang, Jun Lu, Zhijian Lu, Juncai Meng, Peter Orth, Oksana Palyha, Gopal Parthasarathy, Scott P. Salowe, Sujata Sharma, Jennifer Shipman, Stephen Soisson, Alison Strack, Hyewon Youm, Kake Zhao, Debbie Zinc, Hratch Zokian, George Addona, Karen Akinsanya, James R. Tata, Yusheng Xiong, Jason E. Imbriglio

Version 1 posted 09 July 2019

1,084

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Biological and Medicinal Chemistry

Working Paper

Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone

Bingqi Tong, Mai Luo, Yi Xie, Jessica Spradlin, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel Nomura

Version 1 posted 02 April 2020

2,851

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3

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Biological and Medicinal Chemistry

Working Paper

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

Yaxian Zhou, peng teng, Weiping Tang

Version 1 posted 19 August 2020

828

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Biological and Medicinal Chemistry

Working Paper

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs

Miriam Girardini, Chiara Maniaci, Scott J. Hughes, Andrea Testa, Alessio Ciulli

Version 2 posted 19 February 2019

1,726

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Biological and Medicinal Chemistry

Working Paper

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy Murphy, Angus Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli

Version 2 posted 20 October 2021

4,582

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Biological and Medicinal Chemistry

Working Paper

Targeted AURKA degradation: towards new therapeutic agents for neuroblastoma

Muhammad Rishfi, Simon Krols, Fien Martens, Ellen Sanders, Aline Eggermont, Fanny De Vloed, Joshua Robert Goulding, Martijn Risseeuw, Jan Molenaar, Frank Speleman, Bram De wilde, Serge Van Calenbergh, Kaat Durinck

Version 1 posted 19 August 2022

875

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Theoretical and Computational Chemistry

Working Paper

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Junzhuo Liao, Xueqing Nie, Ilona Unarta, Spencer Ericksen, Weiping Tang

Version 3 posted 20 December 2021

2,035

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Biological and Medicinal Chemistry

Working Paper

Bifunctional molecules that induce targeted degradation and transcytosis of extracellular proteins in brain cells

Rebecca Howell, Rinco Wang, David McDonald, David Spiegel

Version 2 posted 19 September 2023

707

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Biological and Medicinal Chemistry

Working Paper

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

Adam G. Bond, Miquel Muñoz i Ordoño, Celia M. Bisbach, Conner Craigon, Nikolai Makukhin, Elizabeth A. Caine, Manjula Nagala, Marjeta Urh, Georg E. Winter, Kristin M. Riching, Alessio Ciulli

Version 1 posted 21 August 2024

2,089

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29 results in Targeted protein degradation in Keywords: Targeted protein degradation

PHOTACs Enable Optical Control of Protein Degradation

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Targeted AURKA degradation: towards new therapeutic agents for neuroblastoma

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Bifunctional molecules that induce targeted degradation and transcytosis of extracellular proteins in brain cells

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

29 results in Keywords: Targeted protein degradation