Search

4 results in Keywords: Redox biochemistry

Biological and Medicinal Chemistry

Bicyclic selenenyl sulfides tune stepwise rates of thiol/selenol addition, resolution, and cyclisation, to reveal cellular constraints for bioreductive probes targeting mammalian thioredoxin reductase

Lukas Zeisel, Lucas Dessen-Weissenhorn, Karoline C. Scholzen, Andrea Madabeni, Laura Orian, Elias S. J. Arnér, Oliver Thorn-Seshold

Version 1 posted 25 February 2025

100

Downloads

Biological and Medicinal Chemistry

Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically

Jan Felber, Lena Poczka, Karoline Scholzen, Lukas Zeisel, Martin S. Maier, Sander Busker, Ulrike Theisen, Christina Brandstädter, Katja Becker, Elias Arnér, Julia Ahlfeld, Oliver Thorn-Seshold

Version 2 posted 17 January 2022

1,048

Downloads

Biological and Medicinal Chemistry

Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe

Lukas Zeisel, Jan G. Felber, Lena Poczka, Karoline Scholzen, Dorian Cheff, Martin S. Maier, Qing Cheng, Min Shen, Matt D. Hall, Elias S. J. Arnér, Julia Thorn-Seshold, Oliver Thorn-Seshold

Version 2 posted 01 March 2022

1,200

Downloads

Biological and Medicinal Chemistry

Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

Lukas Zeisel, Jan G. Felber, Karoline C. Scholzen, Carina Schmitt, Alexander J. Wiegand, Leonid Komissarov, Elias S. J. Arnér, Oliver Thorn-Seshold

Version 2 posted 10 October 2023

1,194

Downloads