Search

Categories

Biological and Medicinal Chemistry

(4)

Content Types

Working Paper

(4)

Published Date

Last 3 years

(4)

Keywords

Pyruvate dehydrogenase

Authors

4 results in Keywords: Pyruvate dehydrogenase

Biological and Medicinal Chemistry

Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase

Alex H. Y. Chan, Terence C. S. Ho, Kwasi Agyei-Owusu, Finian James Leeper

Version 1 posted 06 October 2022

122

Downloads

Biological and Medicinal Chemistry

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

Alex H. Y. Chan, Terence C. S. Ho, Finian James Leeper

Version 1 posted 30 May 2023

99

Downloads

Biological and Medicinal Chemistry

Thiamine Analogues as Tools to Study Pyruvate Dehydrogenase in Cancer: Biochemical, Computational and Cellular Analyses

Finian James Leeper, Alex Chan, Terence Ho, Daniel Parle

Version 1 posted 19 September 2022

206

Downloads

1

Citations

Biological and Medicinal Chemistry

Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes by Triazole-based Thiamine Analogues

Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba, Finian James Leeper

Version 1 posted 25 January 2023

175

Downloads