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Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

benjamin eduful, Sean O'Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph Pilotte, Carrow Wells, William Zuercher, Carolina Catta-Preta, Priscila Zonzini Ramos, André Santiago, rafael Counago, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M. Willson, Daniel E Frigo, John W. Scott, David Drewry

Version 1 posted 28 December 2020

475

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Biological and Medicinal Chemistry

Working Paper

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors

David Quach, Guanghui Tang, Jothi Anantharajan, Nithya Baburajendran, Anders Poulsen, John Wee, Priya Retna, Rong Li, Boping Liu, Doris Tee, Perlyn Kwek, Joma Joy, Wan-Qi Yang, Chong-Jing Zhang, Klement Foo, Thomas Keller, Shao Yao

Version 1 posted 04 February 2021

1,604

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Organic Chemistry

Working Paper

Concise, Gram-Scale Synthesis of Furo[2,3-B]pyridines, with Functional Handles for Chemoselective Cross-Coupling

Sean O'Byrne, Benjamin J. Eduful, Timothy M. Willson, David Drewry

Version 1 posted 17 March 2020

564

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Biological and Medicinal Chemistry

Working Paper

Heterobifunctional Molecules Induce Dephosphorylation of Kinases - a Proof of Concept Study

Sayumi Yamazoe, Steve Staben

Version 1 posted 31 July 2019

1,177

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Biological and Medicinal Chemistry

Working Paper

Development of Potent and Selective PfCLK3 Inhibitors Based on GSK-TCMDC151 as a New Class of Antimalarials

Amit Mahindra, Omar Janha, Kopano Mapesa, Ana Sanchez-Azqueta, Mahmood M. Alam, Andrew Tobin, Andrew Jamieson

Version 1 posted 13 September 2019

803

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Biological and Medicinal Chemistry

Working Paper

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

Alfredo Picado, Apirat Chaikuad, Carrow Wells, Safal Shrestha, William Zuercher, Julie E. Pickett, Frank Kwarcinski, Parvathi Sinha, Chandi de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Drewry, Tim Willson

Version 1 posted 07 July 2020

825

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Organic Chemistry

Working Paper

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Carrow Wells, David Drewry, Julie E. Pickett, Alison D. Axtman

Version 2 posted 18 May 2020

911

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1

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Theoretical and Computational Chemistry

Working Paper

Prediction of Drug-Target Binding Kinetics for Flexible Proteins by Comparative Binding Energy Analysis

Ariane Nunes Alves, Fabian Ormersbach, Rebecca Wade, Ariane Nunes-Alves

Version 2 posted 04 June 2021

586

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Biological and Medicinal Chemistry

Working Paper

How Reactive are Druggable Cysteines in Protein Kinases?

Ernest Awoonor-Williams, Christopher Rowley

Version 1 posted 10 October 2017

1,200

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Biological and Medicinal Chemistry

Working Paper

How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture

Linglan Fang, Jessica Vilas-Boas, sujata chakraborty, zachary potter, Ames Register, Markus Seeliger, Dustin J. Maly

Version 2 posted 23 April 2020

714

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27 results in Kinase in Keywords: Kinase

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors

Concise, Gram-Scale Synthesis of Furo[2,3-B]pyridines, with Functional Handles for Chemoselective Cross-Coupling

Heterobifunctional Molecules Induce Dephosphorylation of Kinases - a Proof of Concept Study

Development of Potent and Selective PfCLK3 Inhibitors Based on GSK-TCMDC151 as a New Class of Antimalarials

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Prediction of Drug-Target Binding Kinetics for Flexible Proteins by Comparative Binding Energy Analysis

How Reactive are Druggable Cysteines in Protein Kinases?

How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture

27 results in Keywords: Kinase