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Biological and Medicinal Chemistry

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A Generative Deep Learning Approach for the Discovery of SARS CoV2 Protease Inhibitors

Noor Shaker, Mohamed Abou-Zleikha, Mubarak AlAmri, Youcef Mehellou

Version 1 posted 23 April 2020

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2

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Biological and Medicinal Chemistry

Working Paper

Tumor Necrosis Factor Alpha Converting Enzyme (TACE) as Possible Therapeutic Target in SARS-CoV-2 Induced Acute Respiratory Distress Syndrome (ARDS)

Joao Batista Junior

Version 1 posted 03 November 2020

1,094

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Biological and Medicinal Chemistry

Working Paper

How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture

Linglan Fang, Jessica Vilas-Boas, sujata chakraborty, zachary potter, Ames Register, Markus Seeliger, Dustin J. Maly

Version 2 posted 23 April 2020

714

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Biological and Medicinal Chemistry

Working Paper

The Effect of ACE2 Inhibitor MLN-4760 on the Interaction of SARS-CoV-2 Spike Protein with Human ACE2: A Molecular Dynamics Study

Babak Nami, Avrin Ghanaeian, Kasra Ghanaeian, Negin Nami

Version 1 posted 22 April 2020

2,766

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6

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Biological and Medicinal Chemistry

Working Paper

A kinetic trapping approach for facile access to 3FaxNeu5Ac and a photo-crosslinkable sialyltransferase probe

Dhanraj Kumawat, Taylor E. Gray, Cole R. Garnier, Duong T. Bui, Zhixiong Li, Zeinab Jame-Chenarboo, Jeremy Jerasi, Warren O. Wong, John S. Klassen, Chantelle J. Capicciotti, Matthew S. Macauley

Version 1 posted 06 August 2024

156

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Biological and Medicinal Chemistry

Working Paper

Cannabinoid-inspired inhibitors of Autotaxin

Mathias Eymery, Kim-Anh Nguyen, Shibom Basu, Jens Hausmann, Viet-Khoa Tran-Nguyen, Hans Peter Seidel, Lola Gutierrez, Ahcène Boumendjel, Andrew McCarthy

Version 1 posted 26 June 2023

133

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Biological and Medicinal Chemistry

Working Paper

Structure-based Discovery of a Series of NSD2-PWWP1 Inhibitors

Na Li, Hong Yang, Ke Liu, Liwei Zhou, Yuting Huang, Danyan Cao, Yanlian Li, Yaoliang Sun, Aisong Yu, Zhiyan Du, Feng Yu, Ying Zhang, Bingyang Wang, Meiyu Geng, Jian Li, Shilin Xu, Bing Xiong, Xun Huang, Tongchao Liu

Version 2 posted 08 December 2021

923

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Biological and Medicinal Chemistry

Working Paper

Rational design of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors

Milan Stefek, Dominika Chalupska, Karel Chalupsky, Michala Zgarbova, Alexandra Dvorakova, Petra Krafcikova, Alice Shi Ming Li, Michal Sala, Milan Dejmek, Tomas Otava, Ema Chaloupecka, Masoud Vedadi, Jan Weber, Helena Mertlikova-Kaiserova, Radim Nencka

Version 1 posted 13 March 2023

329

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Biological and Medicinal Chemistry

Working Paper

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

Alex H. Y. Chan, Terence C. S. Ho, Finian James Leeper

Version 1 posted 30 May 2023

98

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Biological and Medicinal Chemistry

Working Paper

A high-throughput assay for identifying diverse antagonists of the binding interaction between the ACE2 receptor and the dynamic spike proteins of SARS-CoV-2

Rachel Sammons, Amanda Bohanon, Anvinth Kowtha, Audrey Dejong, Eun Cho, Tamer Kaoud, Kevin Dalby

Version 1 posted 09 June 2022

226

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28 results in Inhibitor, Sucralose in Keywords: Inhibitor, Sucralose

A Generative Deep Learning Approach for the Discovery of SARS CoV2 Protease Inhibitors

Tumor Necrosis Factor Alpha Converting Enzyme (TACE) as Possible Therapeutic Target in SARS-CoV-2 Induced Acute Respiratory Distress Syndrome (ARDS)

How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture

The Effect of ACE2 Inhibitor MLN-4760 on the Interaction of SARS-CoV-2 Spike Protein with Human ACE2: A Molecular Dynamics Study

A kinetic trapping approach for facile access to 3FaxNeu5Ac and a photo-crosslinkable sialyltransferase probe

Cannabinoid-inspired inhibitors of Autotaxin

Structure-based Discovery of a Series of NSD2-PWWP1 Inhibitors

Rational design of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

A high-throughput assay for identifying diverse antagonists of the binding interaction between the ACE2 receptor and the dynamic spike proteins of SARS-CoV-2

28 results in Keywords: Inhibitor, Sucralose