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Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation

Zsófia Hegedüs Zsófia Hegedüs, Fruzsina Hobor, Deborah K. Shoemark, sergio Celis, Lu-Yun Lian, Chi Trinh, Richard Sessions, Thomas Edwards, Andrew Wilson

Version 1 posted 05 June 2020

508

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Theoretical and Computational Chemistry

Working Paper

Systemic Evolutionary Chemical Space Exploration For Drug Discovery

Chong Lu, Shien Liu, Weihua Shi, Jun Yu, Zhou Zhou, Xiaoxiao Zhang, Xiaoli Lu, Faji Cai, Ning Xia, Yikai Wang

Version 1 posted 07 December 2021

734

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Biological and Medicinal Chemistry

Working Paper

Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

Andrew J. Whitehouse, Sherine E. Thomas, Karen P. Brown, Alexander Fanourakis, Daniel Chan, M. Daben J. Libardo, Vitor Mendes, Helena I. M. Boshoff, R. Andres Floto, Chris Abell, Tom. L. Blundell, Anthony Coyne

Version 1 posted 16 May 2019

570

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Biological and Medicinal Chemistry

Working Paper

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner

Version 2 posted 19 September 2023

638

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small Molecule Inhibitors

Caroline Buchholz, Molly Sneddon, Joseph McPherson, Sourav Das, Clifford Gee, Michael Grillo, Sergio Chai, Richard Lee, Taosheng Chen, Dan Harki, Anang Shelat, William Pomerantz

Version 1 posted 14 August 2023

204

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Biological and Medicinal Chemistry

Working Paper

Expanding Bioactive Fragment Space with the Generated Database GDB-13s

Ye Buehler, Jean-Louis Reymond

Version 1 posted 19 July 2023

164

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Biological and Medicinal Chemistry

Working Paper

A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments

Markus Tiemann, Eric Nawrotzky, Peter Schmieder, Leon Wehrhan, Silke Bergemann, Vera Martos, Christoph Arkona, Bettina G. Keller, Jörg Rademann

Version 1 posted 08 April 2022

209

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Biological and Medicinal Chemistry

Working Paper

Fragment tailoring strategy to design novel chemical entities as potential binders of novel corona virus main protease

Chinmayee Choudhury

Version 2 posted 27 April 2020

999

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Biological and Medicinal Chemistry

Review

Fragment-based approaches to identify RNA binders

Blessy M. Suresh, Amirhossein Taghavi, Jessica L. Childs-Disney, Matthew D. Disney

Version 1 posted 13 January 2023

666

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Physical Chemistry

Working Paper

Micromolar concentration affinity study on a benchtop NMR spectrometer with secondary 13C labeled hyperpolarized ligands

Olivier Cala, Charlotte Bocquelet, Chloé Gioiosa, Felix Torres, Samuel F. Cousin, Sylvie Guibert, Morgan Ceillier, Venita Busse, Frank Decker, James G. Kempf, Stuart J. Elliott, Quentin Stern, Aurélien Bornet, Sami Jannin

Version 1 posted 24 April 2024

187

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12 results in Fragment-based drug discovery in Keywords: Fragment-based drug discovery

Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation

Systemic Evolutionary Chemical Space Exploration For Drug Discovery

Development of Inhibitors Against Mycobacterium Abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small Molecule Inhibitors

Expanding Bioactive Fragment Space with the Generated Database GDB-13s

A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments

Fragment tailoring strategy to design novel chemical entities as potential binders of novel corona virus main protease

Fragment-based approaches to identify RNA binders

Micromolar concentration affinity study on a benchtop NMR spectrometer with secondary 13C labeled hyperpolarized ligands

12 results in Keywords: Fragment-based drug discovery