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9 results in Keywords: E3 ligase

Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone

Bingqi Tong, Mai Luo, Yi Xie, Jessica Spradlin, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel Nomura

Version 1 posted 02 April 2020

2,778

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Biological and Medicinal Chemistry

Working Paper

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

Michael J. Bond, Ling Chu, Dhanusha A. Nalawansha, Ke Li, Craig Crews

Version 1 posted 10 April 2020

3,665

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Theoretical and Computational Chemistry

Working Paper

Pharmacophore-based ML model to predict ligand selectivity for E3 ligase binders

Reagon Karki, Yojana Gadiya, Philip Gribbon, Andrea Zaliani

Version 1 posted 19 April 2023

330

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Biological and Medicinal Chemistry

Working Paper

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy Murphy, Angus Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli

Version 2 posted 20 October 2021

4,430

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Biological and Medicinal Chemistry

Working Paper

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1

Simon Ng, Alexander Brueckner, Soheila Bahmanjah, Qiaolin Deng, Jennifer Johnston, Lan Ge, Ruchia Duggal, Bahanu Habulihaz, Benjamin Barlock, Sookhee Ha, Ahmad Sadruddin, Constance Yeo, Corey Strickland, Andrea Peier, Brian Henry, Edward Sherer, Anthony Partridge

Version 1 posted 22 December 2021

1,135

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Biological and Medicinal Chemistry

Working Paper

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

Cyrille Kounde, Maria M. Shchepinova, Edward Tate

Version 2 posted 23 December 2019

1,207

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Biological and Medicinal Chemistry

Working Paper

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Stabilizers

Lan Phuong Vu, Claudia Diehl, Ryan Casement, Adam Bond, Christian Steinebach, Nika Strasek, Alesa Bricelj, Andrej Perdih, Gregor Schnakenburg, Izidor Sosic, Alessio Ciulli, Michael Gutschow

Version 2 posted 01 August 2023

1,107

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Biological and Medicinal Chemistry

Review

Molecular glues: The adhesive connecting targeted protein degradation to the clinic

Janet M. Sasso, Rumiana Tenchov, DaSheng Wang, Linda S. Johnson, Xinmei Wang, Qiongqiong Angela Zhou

Version 1 posted 16 June 2022

4,015

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Biological and Medicinal Chemistry

Working Paper

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

Version 2 posted 16 August 2023

2,404

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9 results in E3 ligase in Keywords: E3 ligase

Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

Pharmacophore-based ML model to predict ligand selectivity for E3 ligase binders

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Stabilizers

Molecular glues: The adhesive connecting targeted protein degradation to the clinic

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

9 results in Keywords: E3 ligase