Search

Biological and Medicinal Chemistry

Working Paper

A Promising Strategy Against SARS-CoV-2 Infected Patients: Antisense Therapy

Hasan Cubuk

Version 1 posted 14 September 2020

615

Downloads

Biological and Medicinal Chemistry

Working Paper

Click Activated Protodrugs Against Cancer Increase the Therapeutic Potential of Chemotherapy through Local Capture and Activation

Kui Wu, Nathan Yee, Sangeetha Srinivasan, Amir Mahmoodi, Michael Zakharian, Jose M. Mejia Oneto, Maksim Royzen

Version 2 posted 02 November 2020

2,652

Downloads

Biological and Medicinal Chemistry

Working Paper

Pitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors

Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner

Version 1 posted 24 August 2023

403

Downloads

Biological and Medicinal Chemistry

Working Paper

A lysate-based TR-FRET approach for the facile quantification of cellular drug concentration

N. Connor Payne, Ralph Mazitschek

Version 1 posted 17 January 2024

228

Downloads

Chemical Engineering and Industrial Chemistry

Working Paper

Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-primase Inhibitor Active Pharmaceutical Ingredient

Rodolfo Teixeira, Michael Andresini, Renzo Luisi, Brahim Benyahia

Version 1 posted 12 June 2024

1,050

Downloads

Organic Chemistry

Working Paper

A Robust Crystal Structure Prediction Method to Support Small Molecule Drug Development with Large Scale Validation and Prospective Studies

Dong Zhou, Imanuel Bier, Biswajit Santra, Leif Jacobson, Chuanjie Wu, Adiran Suarez, Barbara Almaguer, Peter Skrdla, Paul Devine, Haoyu Yu, Robert Abel, Richard Friesner, Lingle Wang

Version 2 posted 12 August 2024

1,243

Downloads

Biological and Medicinal Chemistry

Working Paper

DeepDelta: Predicting Pharmacokinetic Improvements of Molecular Derivatives with Deep Learning

Zachary Fralish, Ashley Chen, Paul Skaluba, Daniel Reker

Version 1 posted 11 April 2023

899

Downloads

1

Citations

Analytical Chemistry

Working Paper

Automated Bioanalytical Workflow for Ligand Binding Based Pharmacokinetic Assay Development

Brad Evans, Lai Yeung, Armen Beck, Annie Li, Dong Hun Lee, Gaurav Chopra, Kevin Bateman

Version 1 posted 03 March 2022

531

Downloads

Theoretical and Computational Chemistry

Working Paper

Learning relationships between chemical and physical stability for drug development

Jonathan Fine, Prageeth R Wijewardhane, Sheik Dawood Beer Mohideen, Katelyn Smith, Jameson Bothe, Yogita Krishnamachari, Alexandra Andrews, Peter Wuelfing, Yong Liu, Gaurav Chopra

Version 1 posted 25 January 2022

548

Downloads

Theoretical and Computational Chemistry

Working Paper

Improving Molecular Machine Learning Through Adaptive Subsampling with Active Learning

Yujing Wen, Zhixiong Li, Yan Xiang, Daniel Reker

Version 1 posted 13 February 2023

639

Downloads

1

Citations

Refine Search

10 results in Drug Development in Keywords: Drug Development

A Promising Strategy Against SARS-CoV-2 Infected Patients: Antisense Therapy

Click Activated Protodrugs Against Cancer Increase the Therapeutic Potential of Chemotherapy through Local Capture and Activation

Pitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors

A lysate-based TR-FRET approach for the facile quantification of cellular drug concentration

Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-primase Inhibitor Active Pharmaceutical Ingredient

A Robust Crystal Structure Prediction Method to Support Small Molecule Drug Development with Large Scale Validation and Prospective Studies

DeepDelta: Predicting Pharmacokinetic Improvements of Molecular Derivatives with Deep Learning

Automated Bioanalytical Workflow for Ligand Binding Based Pharmacokinetic Assay Development

Learning relationships between chemical and physical stability for drug development

Improving Molecular Machine Learning Through Adaptive Subsampling with Active Learning

10 results in Keywords: Drug Development