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14 results in Keywords: Covalent Inhibitor

Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment

Andrew Jamieson, Skye Brettell, Omar Jahna, Abbey Begen, Gillian Cann, Niniola Olaniyan, Saumya Sharma, Tamas Yelland, Alison Hole, Benazir Alam, Ross Gillespie, Michael Capper, Graeme Milligan, David Clarke, Andrew Tobin

Version 1 posted 21 May 2024

387

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Organic Chemistry

Working Paper

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless

Version 1 posted 25 April 2022

645

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Biological and Medicinal Chemistry

Working Paper

Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of Beta-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors

Anirban Ghoshal, Álvaro Magalhães, Kesatebrhan Asressu, Mohammad Hossain, Matthew Todd, Timothy Willson

Version 1 posted 30 April 2024

161

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Biological and Medicinal Chemistry

Working Paper

Telomerase Reverse Transcriptase Degradation via a Rationally Designed Covalent Proteolysis Targeting Chimera

Grant Frost, Yue Liu, Stephen Kron, Karl Scheidt

Version 3 posted 27 June 2024

360

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Biological and Medicinal Chemistry

Working Paper

Targeted Covalent Inhibition of Telomerase

Rick Betori, Yue Liu, Ding Wu, Rama Mishra, Scott Cohen, Stephen J. Kron, Karl Scheidt

Version 1 posted 23 July 2019

925

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Biological and Medicinal Chemistry

Working Paper

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Lei Wang, Louis Riel, Bekim Bajrami, Bin Deng, Amy Howell, Xudong Yao

Version 2 posted 13 April 2020

828

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Biological and Medicinal Chemistry

Working Paper

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Anti-Fibrotic Activity

Nattawadee Panyain, Aurélien Godinat, Thomas Lanyon-Hogg, Sofía Lachiondo-Ortega, Edward J. Will, Christelle Soudy, Katie Mason, Sarah Elkhalifa, Lisa M. Smith, Jeanine A. Harrigan, Edward Tate

Version 1 posted 31 October 2019

1,137

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Citations

Biological and Medicinal Chemistry

Working Paper

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

Version 2 posted 16 August 2023

2,465

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Biological and Medicinal Chemistry

Working Paper

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Qinheng Zheng, Jordan L. Woehl, Seiya Kitamura, Diogo Santos-Martins, Christopher J. Smedley, Gencheng Li, Stefano Forli, John E. Moses, Dennis W. Wolan, K. Barry Sharpless

Version 1 posted 15 March 2019

1,665

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Citations

Biological and Medicinal Chemistry

Working Paper

Covalent Bonding Aptamer with Enhanced SARS-CoV-2 RBD-ACE2 Blocking and Pseudovirus Neutralization Activities

Zichen Qin, Yiying Zhu, Yu Xiang

Version 2 posted 28 December 2021

1,861

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14 results in Covalent Inhibitor in Keywords: Covalent Inhibitor

Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of Beta-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors

Telomerase Reverse Transcriptase Degradation via a Rationally Designed Covalent Proteolysis Targeting Chimera

Targeted Covalent Inhibition of Telomerase

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Anti-Fibrotic Activity

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Covalent Bonding Aptamer with Enhanced SARS-CoV-2 RBD-ACE2 Blocking and Pseudovirus Neutralization Activities

14 results in Keywords: Covalent Inhibitor